Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer

Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer

Abstract Background Nomilin is a limonoid compound known for its multiple biological activities, but its role in triple negative breast cancer (TNBC) remains unclear. This study aims to uncover the potential therapeutic effect of nomilin on TNBC and elucidate the specific mechanism of its action. Me...

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Bibliographic Details
Main Authors: Zhixuan Wu, Haoyi Xiang, Xiaowu Wang, Rongrong Zhang, Yangyang Guo, Liangchen Qu, Jingyao Zhou, Yanyi Xiao
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Molecular Medicine
Subjects:
Network pharmacology
Molecular docking
Nomilin
Triple negative breast cancer
PI3K/Akt pathway
Online Access:https://doi.org/10.1186/s10020-024-00928-2
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