Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report
Macrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in ch...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/762863 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566985423060992 |
|---|---|
| author | Jolanta Zuwała-Jagiello Monika Pazgan-Simon Krzysztof Simon Maria Warwas |
| author_facet | Jolanta Zuwała-Jagiello Monika Pazgan-Simon Krzysztof Simon Maria Warwas |
| author_sort | Jolanta Zuwała-Jagiello |
| collection | DOAJ |
| description | Macrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P<0.01 and P<0.05, resp.). The values of PA and hsCRP were more elevated in patients with diabetes than without diabetes (both P<0.01). The positive relationships were between PA and hsCRP levels (P<0.05) and the presence of diabetes (P<0.001). We documented that significant elevation in serum PA levels is associated with diabetes prevalence and increased inflammatory response reflected in hsCRP levels in CHC patients. |
| format | Article |
| id | doaj-art-b7541fbb70624643bb576eff3c6aa3e0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b7541fbb70624643bb576eff3c6aa3e02025-02-03T01:02:38ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/762863762863Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary ReportJolanta Zuwała-Jagiello0Monika Pazgan-Simon1Krzysztof Simon2Maria Warwas3Department of Pharmaceutical Biochemistry, Wroclaw Medical University, PolandClinic of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wroclaw Medical University, PolandClinic of Infectious Diseases, Liver Diseases and Acquired Immune Deficiency, Wroclaw Medical University, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, PolandMacrophage activation seems to be a feature of chronic liver diseases. Picolinic acid (PA) as a macrophage secondary signal causes the activation of interferon-gamma- (IFN-γ-) prime macrophage and triggers cytokine-driven inflammatory reactions. The rationale for seeking increased PA formation in chronic viral hepatitis is based on the involvement of activated macrophages in chronic viral hepatitis-associated inflammation. The aim of this study was to determine serum PA levels in patients with chronic hepatitis C infection, taking into account the presence of diabetes. We assessed PA and high-sensitivity C-reactive protein (hsCRP) as a marker of inflammation in 51 patients with chronic hepatitis C infection (CHC), both with and without diabetes and 40 controls. Compared with the controls, the patients with CHC showed a significant increase in plasma concentrations of PA and hsCRP (P<0.01 and P<0.05, resp.). The values of PA and hsCRP were more elevated in patients with diabetes than without diabetes (both P<0.01). The positive relationships were between PA and hsCRP levels (P<0.05) and the presence of diabetes (P<0.001). We documented that significant elevation in serum PA levels is associated with diabetes prevalence and increased inflammatory response reflected in hsCRP levels in CHC patients.http://dx.doi.org/10.1155/2012/762863 |
| spellingShingle | Jolanta Zuwała-Jagiello Monika Pazgan-Simon Krzysztof Simon Maria Warwas Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report Mediators of Inflammation |
| title | Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report |
| title_full | Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report |
| title_fullStr | Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report |
| title_full_unstemmed | Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report |
| title_short | Picolinic Acid in Patients with Chronic Hepatitis C Infection: A Preliminary Report |
| title_sort | picolinic acid in patients with chronic hepatitis c infection a preliminary report |
| url | http://dx.doi.org/10.1155/2012/762863 |
| work_keys_str_mv | AT jolantazuwałajagiello picolinicacidinpatientswithchronichepatitiscinfectionapreliminaryreport AT monikapazgansimon picolinicacidinpatientswithchronichepatitiscinfectionapreliminaryreport AT krzysztofsimon picolinicacidinpatientswithchronichepatitiscinfectionapreliminaryreport AT mariawarwas picolinicacidinpatientswithchronichepatitiscinfectionapreliminaryreport |