Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum
Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum has created the need for prediction of novel targets as well as leads derived from original molecules with improved activity against a validated drug target. The malaria parasite has a plant plastid-like apico...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/657189 |
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| author | Tabish Qidwai Farrukh Jamal Mohd Y. Khan Bechan Sharma |
| author_facet | Tabish Qidwai Farrukh Jamal Mohd Y. Khan Bechan Sharma |
| author_sort | Tabish Qidwai |
| collection | DOAJ |
| description | Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum has created the need for prediction of novel targets as well as leads derived from original molecules with improved activity against a validated drug target. The malaria parasite has a plant plastid-like apicoplast. To overcome the problem of falciparum malaria, the metabolic pathways in parasite apicoplast have been used as antimalarial drug targets. Among several pathways in apicoplast, isoprenoid biosynthesis is one of the important pathways for parasite as its multiplication in human erythrocytes requires isoprenoids. Therefore targeting this pathway and exploring leads with improved activity is a highly attractive approach. This report has explored progress towards the study of proteins and inhibitors of isoprenoid biosynthesis pathway. For more comprehensive analysis, antimalarial drug-protein interaction has been covered. |
| format | Article |
| id | doaj-art-b7506bdbef1b48b6a2253217595afced |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-b7506bdbef1b48b6a2253217595afced2025-02-03T06:42:18ZengWileyBiochemistry Research International2090-22472090-22552014-01-01201410.1155/2014/657189657189Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparumTabish Qidwai0Farrukh Jamal1Mohd Y. Khan2Bechan Sharma3Department of Biotechnology, Faculty of Engineering & Technology, Raja Balwant Singh, Engineering Technical Campus, Agra 283105, IndiaDepartment of Biochemistry, Dr. Ram Manohar Lohia Avadh University, Faizabad 224001, IndiaDepartment of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, IndiaDepartment of Biochemistry, University of Allahabad, Allahabad, IndiaEmergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum has created the need for prediction of novel targets as well as leads derived from original molecules with improved activity against a validated drug target. The malaria parasite has a plant plastid-like apicoplast. To overcome the problem of falciparum malaria, the metabolic pathways in parasite apicoplast have been used as antimalarial drug targets. Among several pathways in apicoplast, isoprenoid biosynthesis is one of the important pathways for parasite as its multiplication in human erythrocytes requires isoprenoids. Therefore targeting this pathway and exploring leads with improved activity is a highly attractive approach. This report has explored progress towards the study of proteins and inhibitors of isoprenoid biosynthesis pathway. For more comprehensive analysis, antimalarial drug-protein interaction has been covered.http://dx.doi.org/10.1155/2014/657189 |
| spellingShingle | Tabish Qidwai Farrukh Jamal Mohd Y. Khan Bechan Sharma Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum Biochemistry Research International |
| title | Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum |
| title_full | Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum |
| title_fullStr | Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum |
| title_full_unstemmed | Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum |
| title_short | Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum |
| title_sort | exploring drug targets in isoprenoid biosynthetic pathway for plasmodium falciparum |
| url | http://dx.doi.org/10.1155/2014/657189 |
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