The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial
The purpose of this study was to determine the effect of dexmedetomidine on hemodynamic responses to DLT intubation compared to placebo and to assess the adverse effects related to dexmedetomidine. Sixty patients were randomly allocated to receive 0.7 μg/kg dexmedetomidine (n=30) or normal saline (n...
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Wiley
2013-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/236089 |
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| author | Tanyong Pipanmekaporn Yodying Punjasawadwong Somrat Charuluxananan Worawut Lapisatepun Pavena Bunburaphong |
| author_facet | Tanyong Pipanmekaporn Yodying Punjasawadwong Somrat Charuluxananan Worawut Lapisatepun Pavena Bunburaphong |
| author_sort | Tanyong Pipanmekaporn |
| collection | DOAJ |
| description | The purpose of this study was to determine the effect of dexmedetomidine on hemodynamic responses to DLT intubation compared to placebo and to assess the adverse effects related to dexmedetomidine. Sixty patients were randomly allocated to receive 0.7 μg/kg dexmedetomidine (n=30) or normal saline (n=30) 10 minutes before general anesthesia. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) between groups were recorded. During intubation and 10 minutes afterward (T1-T10), the mean SBP, DBP, MAP, HR, and RPP in the control group were significantly higher than those in the dexmedetomidine group throughout the study period except at T1. The mean differences of SBP, DBP, MAP, HR, and RPP were significantly higher in the control group, with the value of 15.2 mmHg, 10.5 mmHg, 14 mmHg, 10.5 beats per minute, and 2,462.8 mmHg min−1. Four patients in the dexmedetomidine group and 1 patient in the control group developed hypotension, while 2 patients in the dexmedetomidine group had bradycardia. Prophylactic dexmedetomidine can attenuate the hemodynamic responses to laryngoscopy and DLT intubation with minimal adverse effects. This trial is registered with ClinicalTrials.gov NCT01289769. |
| format | Article |
| id | doaj-art-b72adcb5ceb7442fad5b1a6ed90ffc2a |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Anesthesiology Research and Practice |
| spelling | doaj-art-b72adcb5ceb7442fad5b1a6ed90ffc2a2025-02-03T06:13:08ZengWileyAnesthesiology Research and Practice1687-69621687-69702013-01-01201310.1155/2013/236089236089The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled TrialTanyong Pipanmekaporn0Yodying Punjasawadwong1Somrat Charuluxananan2Worawut Lapisatepun3Pavena Bunburaphong4Clinical Epidemiology Program, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandDepartment of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandThe purpose of this study was to determine the effect of dexmedetomidine on hemodynamic responses to DLT intubation compared to placebo and to assess the adverse effects related to dexmedetomidine. Sixty patients were randomly allocated to receive 0.7 μg/kg dexmedetomidine (n=30) or normal saline (n=30) 10 minutes before general anesthesia. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and rate pressure product (RPP) between groups were recorded. During intubation and 10 minutes afterward (T1-T10), the mean SBP, DBP, MAP, HR, and RPP in the control group were significantly higher than those in the dexmedetomidine group throughout the study period except at T1. The mean differences of SBP, DBP, MAP, HR, and RPP were significantly higher in the control group, with the value of 15.2 mmHg, 10.5 mmHg, 14 mmHg, 10.5 beats per minute, and 2,462.8 mmHg min−1. Four patients in the dexmedetomidine group and 1 patient in the control group developed hypotension, while 2 patients in the dexmedetomidine group had bradycardia. Prophylactic dexmedetomidine can attenuate the hemodynamic responses to laryngoscopy and DLT intubation with minimal adverse effects. This trial is registered with ClinicalTrials.gov NCT01289769.http://dx.doi.org/10.1155/2013/236089 |
| spellingShingle | Tanyong Pipanmekaporn Yodying Punjasawadwong Somrat Charuluxananan Worawut Lapisatepun Pavena Bunburaphong The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial Anesthesiology Research and Practice |
| title | The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial |
| title_full | The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial |
| title_fullStr | The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial |
| title_full_unstemmed | The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial |
| title_short | The Effect of Prophylactic Dexmedetomidine on Hemodynamic Disturbances to Double-Lumen Endotracheal Intubation: A Prospective, Randomized, Double-Blind, and Placebo-Controlled Trial |
| title_sort | effect of prophylactic dexmedetomidine on hemodynamic disturbances to double lumen endotracheal intubation a prospective randomized double blind and placebo controlled trial |
| url | http://dx.doi.org/10.1155/2013/236089 |
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