Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy
Diabetic retinopathy is the main microvascular complication of diabetes and the first blinding eye disease in the working-age population. Oxidative stress is an important pathogenesis of diabetic retinopathy. Plant metabolites can be divided into two types: primary metabolites and secondary metaboli...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1517964/full |
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| author | Tianyao Gong Dongmei Wang Dongmei Wang Jinyan Wang Qun Huang Haiyan Zhang Chunmeng Liu Xinglin Liu Hejiang Ye |
| author_facet | Tianyao Gong Dongmei Wang Dongmei Wang Jinyan Wang Qun Huang Haiyan Zhang Chunmeng Liu Xinglin Liu Hejiang Ye |
| author_sort | Tianyao Gong |
| collection | DOAJ |
| description | Diabetic retinopathy is the main microvascular complication of diabetes and the first blinding eye disease in the working-age population. Oxidative stress is an important pathogenesis of diabetic retinopathy. Plant metabolites can be divided into two types: primary metabolites and secondary metabolites, secondary metabolites are the main active components and important sources for developing new drugs. It has unique effect in the treatment of diabetic retinopathy. However, the research on the intervention mechanism of plant metabolites in diabetic retinopathy are still relatively shallow, which limit the application of plant metabolites. With the deepening of research, more and more plant metabolites have been reported to play a role in treating diabetic retinopathy through anti-oxidative stress, including polyphenols, polysaccharides, saponins, alkaloids, etc. Therefore, this article reviewed the potential of plant metabolites in the treatment of diabetic retinopathy in the last 10 years and elucidated their mechanism of action. We hope to provide some references for the application of plant metabolites and provide valuable resources for the research and development of new drugs for diabetic retinopathy. |
| format | Article |
| id | doaj-art-b72a7a2a059b42c8b00baa26f657ea8d |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b72a7a2a059b42c8b00baa26f657ea8d2025-02-05T05:17:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15179641517964Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathyTianyao Gong0Dongmei Wang1Dongmei Wang2Jinyan Wang3Qun Huang4Haiyan Zhang5Chunmeng Liu6Xinglin Liu7Hejiang Ye8Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaEye School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaEye School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaEye School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaEye School of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Management, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDiabetic retinopathy is the main microvascular complication of diabetes and the first blinding eye disease in the working-age population. Oxidative stress is an important pathogenesis of diabetic retinopathy. Plant metabolites can be divided into two types: primary metabolites and secondary metabolites, secondary metabolites are the main active components and important sources for developing new drugs. It has unique effect in the treatment of diabetic retinopathy. However, the research on the intervention mechanism of plant metabolites in diabetic retinopathy are still relatively shallow, which limit the application of plant metabolites. With the deepening of research, more and more plant metabolites have been reported to play a role in treating diabetic retinopathy through anti-oxidative stress, including polyphenols, polysaccharides, saponins, alkaloids, etc. Therefore, this article reviewed the potential of plant metabolites in the treatment of diabetic retinopathy in the last 10 years and elucidated their mechanism of action. We hope to provide some references for the application of plant metabolites and provide valuable resources for the research and development of new drugs for diabetic retinopathy.https://www.frontiersin.org/articles/10.3389/fphar.2025.1517964/fullplant metabolitesoxidative stressdiabetic retinopathypolyphenolspolysaccharidesaponins |
| spellingShingle | Tianyao Gong Dongmei Wang Dongmei Wang Jinyan Wang Qun Huang Haiyan Zhang Chunmeng Liu Xinglin Liu Hejiang Ye Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy Frontiers in Pharmacology plant metabolites oxidative stress diabetic retinopathy polyphenols polysaccharide saponins |
| title | Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy |
| title_full | Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy |
| title_fullStr | Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy |
| title_full_unstemmed | Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy |
| title_short | Study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy |
| title_sort | study on the mechanism of plant metabolites to intervene oxidative stress in diabetic retinopathy |
| topic | plant metabolites oxidative stress diabetic retinopathy polyphenols polysaccharide saponins |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1517964/full |
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