Environmentally Friendly Green <i>O</i>-Alkylation Reaction for Ethenzamide Synthesis

Environmentally Friendly Green <i>O</i>-Alkylation Reaction for Ethenzamide Synthesis

Ethenzamide (2-ethoxybenzamide), besides acetylsalicylic acid, is one of the mostly used salicylic acid derivatives in pharmaceuticals. It has analgesic and anti-inflammatory effects that originate from the inhibition of cyclooxygenase (COX-1) activity, thus blocking prostaglandin synthesis. In this...

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Bibliographic Details
Main Authors: Paulina Niedziejko-Ćwiertnia, Anna Karolina Drabczyk, Damian Kułaga, Patrycja Podobińska, Wojciech Bachowski, Kamila Zeńczak-Tomera, Piotr Michorczyk, Ruilong Sheng, Jolanta Jaśkowska
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Applied Sciences
Subjects:
<i>O</i>-alkylation
green synthesis
salicylamide
ethenzamide
phase transfer catalysts (PTC)
solvent-free synthesis
Online Access:https://www.mdpi.com/2076-3417/15/3/1342
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