Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors
Background: Cluster of differentiation 44 (CD44) is the most commonly reported immune marker of the cancer stem cells in renal cell carcinoma.Objectives: To assess the frequency of CD44 expression in renal tumors, to assess the expression of CD44 in different histological types, and to detect its as...
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University of Anbar
2025-01-01
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| Series: | Al-Anbar Medical Journal |
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| Online Access: | https://amj.uoanbar.edu.iq/article_185669_8dfa3277d44fd3b065a7b6a6baf38114.pdf |
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| author | Banan Mohammed khalid Abdulfattah Khattab Payman Salim |
| author_facet | Banan Mohammed khalid Abdulfattah Khattab Payman Salim |
| author_sort | Banan Mohammed |
| collection | DOAJ |
| description | Background: Cluster of differentiation 44 (CD44) is the most commonly reported immune marker of the cancer stem cells in renal cell carcinoma.Objectives: To assess the frequency of CD44 expression in renal tumors, to assess the expression of CD44 in different histological types, and to detect its association with variable clinicopathological parameters.Materials and methods: In this retrospective case series study, 76 cases of primary renal tumors were obtained by nephrectomy, and a study of CD44 was done by using the immunohistochemical technique.Results: The age of the patients ranged from 29-82 years with a mean of 54.8 ±11.96 with a male to female ratio of 1.05:1. Tumor size ranged from 2-17 cm with a mean of 6.2 ±3.23. Clear cell renal cell carcinoma was forming 61.83% of the cases. Among all cases, a positive CD44 expression was observed in 35 (46.05%) cases; among the malignant cases, CD44 was positive in 32 (45.71%). CD44 immunohistochemical stain showed significantly higher expression in cases with higher nuclear grade and tumor stage (P-value of 0.0376 and 0.0075, respectively). CD44 cannot differentiate between benign and malignant renal tumors.Conclusion: CD44 immune marker can be used as a prognostic factor to predict the aggressive behavior of renal tumors. It can also be used with standard prognostic markers to add prognostic information for subgrouping cases within the same grade and stage. |
| format | Article |
| id | doaj-art-b707dbedc2a4426fac55d4415e58173c |
| institution | Kabale University |
| issn | 2706-6207 2664-3154 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | University of Anbar |
| record_format | Article |
| series | Al-Anbar Medical Journal |
| spelling | doaj-art-b707dbedc2a4426fac55d4415e58173c2025-01-21T21:57:32ZengUniversity of AnbarAl-Anbar Medical Journal2706-62072664-31542025-01-01211556010.33091/amj.2024.153497.1927185669Assessment of Immuno-histochemical Expression of CD44 in Renal TumorsBanan Mohammed0khalid Abdulfattah Khattab1Payman Salim2Department of Pathology, College of Medicine, University of Mosul, Mosul, Iraq.Department of Pathology, College of Medicine, University of Mosul, Mosul, Iraq.Department of Pathology, Medicolegal Institute, Erbil, Kurdistan, Iraq.Background: Cluster of differentiation 44 (CD44) is the most commonly reported immune marker of the cancer stem cells in renal cell carcinoma.Objectives: To assess the frequency of CD44 expression in renal tumors, to assess the expression of CD44 in different histological types, and to detect its association with variable clinicopathological parameters.Materials and methods: In this retrospective case series study, 76 cases of primary renal tumors were obtained by nephrectomy, and a study of CD44 was done by using the immunohistochemical technique.Results: The age of the patients ranged from 29-82 years with a mean of 54.8 ±11.96 with a male to female ratio of 1.05:1. Tumor size ranged from 2-17 cm with a mean of 6.2 ±3.23. Clear cell renal cell carcinoma was forming 61.83% of the cases. Among all cases, a positive CD44 expression was observed in 35 (46.05%) cases; among the malignant cases, CD44 was positive in 32 (45.71%). CD44 immunohistochemical stain showed significantly higher expression in cases with higher nuclear grade and tumor stage (P-value of 0.0376 and 0.0075, respectively). CD44 cannot differentiate between benign and malignant renal tumors.Conclusion: CD44 immune marker can be used as a prognostic factor to predict the aggressive behavior of renal tumors. It can also be used with standard prognostic markers to add prognostic information for subgrouping cases within the same grade and stage.https://amj.uoanbar.edu.iq/article_185669_8dfa3277d44fd3b065a7b6a6baf38114.pdfkeywords: renal cell carcinomacd44immunohistochemicalexpressionprognosis |
| spellingShingle | Banan Mohammed khalid Abdulfattah Khattab Payman Salim Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors Al-Anbar Medical Journal keywords: renal cell carcinoma cd44 immunohistochemical expression prognosis |
| title | Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors |
| title_full | Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors |
| title_fullStr | Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors |
| title_full_unstemmed | Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors |
| title_short | Assessment of Immuno-histochemical Expression of CD44 in Renal Tumors |
| title_sort | assessment of immuno histochemical expression of cd44 in renal tumors |
| topic | keywords: renal cell carcinoma cd44 immunohistochemical expression prognosis |
| url | https://amj.uoanbar.edu.iq/article_185669_8dfa3277d44fd3b065a7b6a6baf38114.pdf |
| work_keys_str_mv | AT bananmohammed assessmentofimmunohistochemicalexpressionofcd44inrenaltumors AT khalidabdulfattahkhattab assessmentofimmunohistochemicalexpressionofcd44inrenaltumors AT paymansalim assessmentofimmunohistochemicalexpressionofcd44inrenaltumors |