Construction and characterization of chimeric FcγR T cells for universal T cell therapy

Construction and characterization of chimeric FcγR T cells for universal T cell therapy

Abstract Background Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered chimeric Fcγ receptor (FcγR) T cells and tested their potential as a versatile platform for universal T cell therapy. Methods Chimeric FcγR (C...

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Bibliographic Details
Main Authors: Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Experimental Hematology & Oncology
Subjects:
FcγR
Universal CAR T
Off-the-shelf CAR T
Rituximab
Herceptin
Lymphoma
Online Access:https://doi.org/10.1186/s40164-025-00595-x
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