Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury
The aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion. Rabbits received regional ischemia by 30 min of left anterior descending coronary...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Anesthesiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/521084 |
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| author | Hitoshi Yui Uno Imaizumi Hisashi Beppu Mitsuhiro Ito Munetaka Furuya Hirofumi Arisaka Kazu-Ichi Yoshida |
| author_facet | Hitoshi Yui Uno Imaizumi Hisashi Beppu Mitsuhiro Ito Munetaka Furuya Hirofumi Arisaka Kazu-Ichi Yoshida |
| author_sort | Hitoshi Yui |
| collection | DOAJ |
| description | The aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion. Rabbits received regional ischemia by 30 min of left anterior descending coronary artery occlusion followed by 3 hours of reperfusion under ketamine and xylazine anesthesia. The animals were randomly assigned to the following 4 treatment groups: a control group, a verapamil group, a nicardipine group, and a nitroglycerin group. A continuous infusion of verapamil, nicardipine, or nitroglycerin was initiated 5 min prior to ischemia. Infarct size/area at risk decreased in verapamil, and nitroglycerin. The incidence of ischemia-induced arrhythmia decreased in nicardipine, verapamil and nitroglycerin. The incidence of reperfusion-induced arrhythmias decreased in verapamil and nitroglycerin. From the present experimental results, verapamil and nitroglycerin rather than nicardipine did afford significant protection to the heart subjected to ischemia and reperfusion in a rabbit model. |
| format | Article |
| id | doaj-art-b6f61f7da51044d39703a49fc0aaff7f |
| institution | Kabale University |
| issn | 1687-6962 1687-6970 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anesthesiology Research and Practice |
| spelling | doaj-art-b6f61f7da51044d39703a49fc0aaff7f2025-02-03T05:59:17ZengWileyAnesthesiology Research and Practice1687-69621687-69702011-01-01201110.1155/2011/521084521084Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion InjuryHitoshi Yui0Uno Imaizumi1Hisashi Beppu2Mitsuhiro Ito3Munetaka Furuya4Hirofumi Arisaka5Kazu-Ichi Yoshida6Division of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanDivision of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanDivision of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanDivision of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanDivision of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanDivision of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanDivision of Anesthesiology, Department of Clinical Care Medicine, Kanagawa Dental College, 82 Inaokacho, Yokosuka-shi, Kanagawa 238-8580, JapanThe aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion. Rabbits received regional ischemia by 30 min of left anterior descending coronary artery occlusion followed by 3 hours of reperfusion under ketamine and xylazine anesthesia. The animals were randomly assigned to the following 4 treatment groups: a control group, a verapamil group, a nicardipine group, and a nitroglycerin group. A continuous infusion of verapamil, nicardipine, or nitroglycerin was initiated 5 min prior to ischemia. Infarct size/area at risk decreased in verapamil, and nitroglycerin. The incidence of ischemia-induced arrhythmia decreased in nicardipine, verapamil and nitroglycerin. The incidence of reperfusion-induced arrhythmias decreased in verapamil and nitroglycerin. From the present experimental results, verapamil and nitroglycerin rather than nicardipine did afford significant protection to the heart subjected to ischemia and reperfusion in a rabbit model.http://dx.doi.org/10.1155/2011/521084 |
| spellingShingle | Hitoshi Yui Uno Imaizumi Hisashi Beppu Mitsuhiro Ito Munetaka Furuya Hirofumi Arisaka Kazu-Ichi Yoshida Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury Anesthesiology Research and Practice |
| title | Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury |
| title_full | Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury |
| title_fullStr | Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury |
| title_full_unstemmed | Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury |
| title_short | Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/Reperfusion Injury |
| title_sort | comparative effects of verapamil nicardipine and nitroglycerin on myocardial ischemia reperfusion injury |
| url | http://dx.doi.org/10.1155/2011/521084 |
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