RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes
Abstract Type 2 diabetes mellitus (T2DM), a prevalent chronic metabolic disorder, is closely linked to persistent low-grade inflammation, significantly contributing to its development and progression. This review provides a comprehensive examination of the inflammatory mechanisms underlying T2DM, fo...
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| Format: | Article |
| Language: | English |
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BMC
2024-06-01
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| Series: | Diabetology & Metabolic Syndrome |
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| Online Access: | https://doi.org/10.1186/s13098-024-01369-x |
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| _version_ | 1832585519525003264 |
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| author | Jianbin Guan Haimiti Abudouaini Kaiyuan Lin Kaitan Yang |
| author_facet | Jianbin Guan Haimiti Abudouaini Kaiyuan Lin Kaitan Yang |
| author_sort | Jianbin Guan |
| collection | DOAJ |
| description | Abstract Type 2 diabetes mellitus (T2DM), a prevalent chronic metabolic disorder, is closely linked to persistent low-grade inflammation, significantly contributing to its development and progression. This review provides a comprehensive examination of the inflammatory mechanisms underlying T2DM, focusing on the role of the NLRP3 inflammasome and interleukin-1β (IL-1β) in mediating inflammatory responses. We discuss the therapeutic potential of IL-1 inhibitors and colchicine, highlighting their mechanisms in inhibiting the NLRP3 inflammasome and reducing IL-1β production. Recent studies indicate that these agents could effectively mitigate inflammation, offering promising avenues for the prevention and management of T2DM. By exploring the intricate connections between metabolic disturbances and chronic inflammation, this review underscores the need for novel anti-inflammatory strategies to address T2DM and its complications. |
| format | Article |
| id | doaj-art-b6e12110a5e54bb2b5db674646284d88 |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-b6e12110a5e54bb2b5db674646284d882025-01-26T12:45:23ZengBMCDiabetology & Metabolic Syndrome1758-59962024-06-0116111810.1186/s13098-024-01369-xRETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetesJianbin Guan0Haimiti Abudouaini1Kaiyuan Lin2Kaitan Yang3Honghui-Hospital, Xi’an Jiaotong UniversityHonghui-Hospital, Xi’an Jiaotong UniversityHonghui-Hospital, Xi’an Jiaotong UniversityHonghui-Hospital, Xi’an Jiaotong UniversityAbstract Type 2 diabetes mellitus (T2DM), a prevalent chronic metabolic disorder, is closely linked to persistent low-grade inflammation, significantly contributing to its development and progression. This review provides a comprehensive examination of the inflammatory mechanisms underlying T2DM, focusing on the role of the NLRP3 inflammasome and interleukin-1β (IL-1β) in mediating inflammatory responses. We discuss the therapeutic potential of IL-1 inhibitors and colchicine, highlighting their mechanisms in inhibiting the NLRP3 inflammasome and reducing IL-1β production. Recent studies indicate that these agents could effectively mitigate inflammation, offering promising avenues for the prevention and management of T2DM. By exploring the intricate connections between metabolic disturbances and chronic inflammation, this review underscores the need for novel anti-inflammatory strategies to address T2DM and its complications.https://doi.org/10.1186/s13098-024-01369-xColchicineIL-1 inhibitorsChronic inflammationNLRP3 inflammasomeType 2 Diabetes (T2DM) |
| spellingShingle | Jianbin Guan Haimiti Abudouaini Kaiyuan Lin Kaitan Yang RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes Diabetology & Metabolic Syndrome Colchicine IL-1 inhibitors Chronic inflammation NLRP3 inflammasome Type 2 Diabetes (T2DM) |
| title | RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes |
| title_full | RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes |
| title_fullStr | RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes |
| title_full_unstemmed | RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes |
| title_short | RETRACTED ARTICLE: Emerging insights into the role of IL-1 inhibitors and colchicine for inflammation control in type 2 diabetes |
| title_sort | retracted article emerging insights into the role of il 1 inhibitors and colchicine for inflammation control in type 2 diabetes |
| topic | Colchicine IL-1 inhibitors Chronic inflammation NLRP3 inflammasome Type 2 Diabetes (T2DM) |
| url | https://doi.org/10.1186/s13098-024-01369-x |
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