Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation
The stability against various environmental stresses of the curcumin-loaded secondary and tertiary emulsions that was emulsified by whey protein isolate (WPI) and coated by chitosan (CHI), carboxymethyl konjac glucomannan (CMKGM), or their combination through layer-by-layer assembly was investigated...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022001707 |
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| author | Luhui Wang Xinru Zhang Junxia Xiao Jiayi Shi |
| author_facet | Luhui Wang Xinru Zhang Junxia Xiao Jiayi Shi |
| author_sort | Luhui Wang |
| collection | DOAJ |
| description | The stability against various environmental stresses of the curcumin-loaded secondary and tertiary emulsions that was emulsified by whey protein isolate (WPI) and coated by chitosan (CHI), carboxymethyl konjac glucomannan (CMKGM), or their combination through layer-by-layer assembly was investigated. Generally, the multilayered emulsions were destabilized in high NaCl concentrations or medium pH that could interrupt the electrostatic interaction between the three polyelectrolytes or deprotonate CHI, indicating that electrostatic interaction played an important role in the stability of emulsions. Compared with the primary emulsion that was solely stabilized by WPI, extra coating with CHI and CMKGM generally increased the stability of the emulsion against repeated freezing-thawing, improved the retention of curcumin against heating, UV irradiation, and long-term storage, and the effects were more remarkable in the tertiary emulsion with CMKGM locating in the outmost layer. Since CMKGM has shown the colon-targeted delivery potency, the multilayered emulsions assembled by layer-by-layer deposition, especially the tertiary emulsion, could be used as an effective carrier for the targeted delivery of curcumin. |
| format | Article |
| id | doaj-art-b6c58ed6d8b04d5b995b67ab113e90bd |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b6c58ed6d8b04d5b995b67ab113e90bd2025-02-02T23:24:43ZengTsinghua University PressFood Science and Human Wellness2213-45302023-03-01122555563Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluationLuhui Wang0Xinru Zhang1Junxia Xiao2Jiayi Shi3College of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China; College of Food Science and Engineering, Ocean University of China, Qingdao 266109, ChinaCollege of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, ChinaCollege of Food Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China; Corresponding authors.College of Food Science and Engineering, Nanjing University of Finance & Economics, Nanjing 210023, China; Corresponding authors.The stability against various environmental stresses of the curcumin-loaded secondary and tertiary emulsions that was emulsified by whey protein isolate (WPI) and coated by chitosan (CHI), carboxymethyl konjac glucomannan (CMKGM), or their combination through layer-by-layer assembly was investigated. Generally, the multilayered emulsions were destabilized in high NaCl concentrations or medium pH that could interrupt the electrostatic interaction between the three polyelectrolytes or deprotonate CHI, indicating that electrostatic interaction played an important role in the stability of emulsions. Compared with the primary emulsion that was solely stabilized by WPI, extra coating with CHI and CMKGM generally increased the stability of the emulsion against repeated freezing-thawing, improved the retention of curcumin against heating, UV irradiation, and long-term storage, and the effects were more remarkable in the tertiary emulsion with CMKGM locating in the outmost layer. Since CMKGM has shown the colon-targeted delivery potency, the multilayered emulsions assembled by layer-by-layer deposition, especially the tertiary emulsion, could be used as an effective carrier for the targeted delivery of curcumin.http://www.sciencedirect.com/science/article/pii/S2213453022001707CurcuminMultilayered emulsionLayer-by-layer assemblyCarboxymethyl konjac glucomannanElectrostatic interaction |
| spellingShingle | Luhui Wang Xinru Zhang Junxia Xiao Jiayi Shi Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation Food Science and Human Wellness Curcumin Multilayered emulsion Layer-by-layer assembly Carboxymethyl konjac glucomannan Electrostatic interaction |
| title | Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation |
| title_full | Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation |
| title_fullStr | Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation |
| title_full_unstemmed | Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation |
| title_short | Effect of carboxymethyl konjac glucomannan coating on curcumin-loaded multilayered emulsion: stability evaluation |
| title_sort | effect of carboxymethyl konjac glucomannan coating on curcumin loaded multilayered emulsion stability evaluation |
| topic | Curcumin Multilayered emulsion Layer-by-layer assembly Carboxymethyl konjac glucomannan Electrostatic interaction |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022001707 |
| work_keys_str_mv | AT luhuiwang effectofcarboxymethylkonjacglucomannancoatingoncurcuminloadedmultilayeredemulsionstabilityevaluation AT xinruzhang effectofcarboxymethylkonjacglucomannancoatingoncurcuminloadedmultilayeredemulsionstabilityevaluation AT junxiaxiao effectofcarboxymethylkonjacglucomannancoatingoncurcuminloadedmultilayeredemulsionstabilityevaluation AT jiayishi effectofcarboxymethylkonjacglucomannancoatingoncurcuminloadedmultilayeredemulsionstabilityevaluation |