Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients

Purpose. Transitional cell carcinoma (TCC) affecting the graft after renal transplantation is a very infrequent way of presentation of this tumor. Our aim is to present our single institution experience with 2 cases, as well as to perform a review of the literature about this tumor after the transp...

Full description

Saved in:
Bibliographic Details
Main Authors: Vital Hevia, Victoria Gómez, Sara Álvarez, Víctor Díez Nicolás, Carmen Gómez del Cañizo, Andrea Orosa, Cristina Galeano Álvarez, F. J. Burgos Revilla
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Transplantation
Online Access:http://dx.doi.org/10.1155/2013/196528
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832554795537268736
author Vital Hevia
Victoria Gómez
Sara Álvarez
Víctor Díez Nicolás
Carmen Gómez del Cañizo
Andrea Orosa
Cristina Galeano Álvarez
F. J. Burgos Revilla
author_facet Vital Hevia
Victoria Gómez
Sara Álvarez
Víctor Díez Nicolás
Carmen Gómez del Cañizo
Andrea Orosa
Cristina Galeano Álvarez
F. J. Burgos Revilla
author_sort Vital Hevia
collection DOAJ
description Purpose. Transitional cell carcinoma (TCC) affecting the graft after renal transplantation is a very infrequent way of presentation of this tumor. Our aim is to present our single institution experience with 2 cases, as well as to perform a review of the literature about this tumor after the transplant. Materials and Methods. TCC of the graft developed in 2 of 1365 patients from 1977 to 2010, both cases in women. Data were analyzed for incidence, clinical presentation, treatment, and outcomes. Results. Both cases occurred in 2 mid-age women and resulted to be high grade and locally advanced TCCs, representing an incidence of 0,14% (2/1365). Clinical presentation was urinary obstruction for the first case and incidental ultrasound finding for the second. Preoperative staging was made with CT, cytology, pyelography, ureterorenoscopy, and biopsy. Treatment performed was nephroureterectomy of the graft with bladder cuff and regional lymphadenectomy. Pathological examination showed in both cases a locally advanced and high grade urothelial carcinoma of the pelvis allograft. After 24 and 14 months of followup, both patients are disease free. Conclusions. TCC of the kidney graft is an infrequent tumor that has only been reported in a few cases in the literature. It usually appears at a lower age, more often locally advanced, and with poor differentiation. A multidisciplinary approach to treatment should be required in these cases.
format Article
id doaj-art-b6ae7a1ceb564e678c5ca751b0e37f0d
institution Kabale University
issn 2090-6943
2090-6951
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series Case Reports in Transplantation
spelling doaj-art-b6ae7a1ceb564e678c5ca751b0e37f0d2025-02-03T05:50:30ZengWileyCase Reports in Transplantation2090-69432090-69512013-01-01201310.1155/2013/196528196528Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant RecipientsVital Hevia0Victoria Gómez1Sara Álvarez2Víctor Díez Nicolás3Carmen Gómez del Cañizo4Andrea Orosa5Cristina Galeano Álvarez6F. J. Burgos Revilla7Department of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Nephrology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainDepartment of Urology, Hospital Ramón y Cajal, Ctra. Colmenar km 9,100, 28034 Madrid, SpainPurpose. Transitional cell carcinoma (TCC) affecting the graft after renal transplantation is a very infrequent way of presentation of this tumor. Our aim is to present our single institution experience with 2 cases, as well as to perform a review of the literature about this tumor after the transplant. Materials and Methods. TCC of the graft developed in 2 of 1365 patients from 1977 to 2010, both cases in women. Data were analyzed for incidence, clinical presentation, treatment, and outcomes. Results. Both cases occurred in 2 mid-age women and resulted to be high grade and locally advanced TCCs, representing an incidence of 0,14% (2/1365). Clinical presentation was urinary obstruction for the first case and incidental ultrasound finding for the second. Preoperative staging was made with CT, cytology, pyelography, ureterorenoscopy, and biopsy. Treatment performed was nephroureterectomy of the graft with bladder cuff and regional lymphadenectomy. Pathological examination showed in both cases a locally advanced and high grade urothelial carcinoma of the pelvis allograft. After 24 and 14 months of followup, both patients are disease free. Conclusions. TCC of the kidney graft is an infrequent tumor that has only been reported in a few cases in the literature. It usually appears at a lower age, more often locally advanced, and with poor differentiation. A multidisciplinary approach to treatment should be required in these cases.http://dx.doi.org/10.1155/2013/196528
spellingShingle Vital Hevia
Victoria Gómez
Sara Álvarez
Víctor Díez Nicolás
Carmen Gómez del Cañizo
Andrea Orosa
Cristina Galeano Álvarez
F. J. Burgos Revilla
Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients
Case Reports in Transplantation
title Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients
title_full Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients
title_fullStr Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients
title_full_unstemmed Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients
title_short Transitional Cell Carcinoma of the Kidney Graft: An Extremely Uncommon Presentation of Tumor in Renal Transplant Recipients
title_sort transitional cell carcinoma of the kidney graft an extremely uncommon presentation of tumor in renal transplant recipients
url http://dx.doi.org/10.1155/2013/196528
work_keys_str_mv AT vitalhevia transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT victoriagomez transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT saraalvarez transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT victordieznicolas transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT carmengomezdelcanizo transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT andreaorosa transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT cristinagaleanoalvarez transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients
AT fjburgosrevilla transitionalcellcarcinomaofthekidneygraftanextremelyuncommonpresentationoftumorinrenaltransplantrecipients