Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer
Background. Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified. Aims. This study is aimed at determining the association of XRCC3 Thr241Met (rs861539), XRCC4 G(-1394) T (rs6869366) DNA repair and BAX G(-248) A (rs46...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2022/5817841 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553006241939456 |
|---|---|
| author | Emre Ozoran Fadime Didem Can Trabulus Duygu Erhan Bahadir Batar Mehmet Guven |
| author_facet | Emre Ozoran Fadime Didem Can Trabulus Duygu Erhan Bahadir Batar Mehmet Guven |
| author_sort | Emre Ozoran |
| collection | DOAJ |
| description | Background. Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified. Aims. This study is aimed at determining the association of XRCC3 Thr241Met (rs861539), XRCC4 G(-1394) T (rs6869366) DNA repair and BAX G(-248) A (rs4645878), and BCL2 C(-938) A (rs2279115) apoptotic gene polymorphisms with breast cancer. Materials and Methods. Genetic analysis was performed using peripheral blood samples. Gene polymorphisms were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. 175 patients and 158 healthy controls were enrolled in the study. Results. Breast cancer risk was 5.43 times more in individuals with AA genotype of Bax G(-248) A (rs4645878) (P=0.002). The risk of metastasis was 11 times with this genotype. It was associated with 6 times more risk of having a tumor larger than 2 cm. The risk of breast cancer was 2.77 times more in individuals carrying the Met/Met genotype of XRCC3 Thr241Met (rs861539) (P=0.009). The risk of having advanced clinical stage (stage III+IV) with the Met/Met genotype was 4 times more increased. No relationship with breast cancer was found with XRCC4 G(-1394) T (rs6869366) and BCL2 C(-938) A (rs2279115) gene polymorphisms. Conclusion. Multicenter trials using subjects with genetic variations are needed to establish the relationship between breast cancer and single gene polymorphism. |
| format | Article |
| id | doaj-art-b6aa6a93a9fb4c668f076f42d73b27b4 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-b6aa6a93a9fb4c668f076f42d73b27b42025-02-03T05:57:20ZengWileyInternational Journal of Breast Cancer2090-31892022-01-01202210.1155/2022/5817841Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast CancerEmre Ozoran0Fadime Didem Can Trabulus1Duygu Erhan2Bahadir Batar3Mehmet Guven4Department of General SurgeryDepartment of General SurgeryDepartment of Medical BiologyDepartment of Medical BiologyDepartment of Medical BiologyBackground. Breast cancer is the most common malignancy in women. Genetic risk factors associated with breast cancer incidence have been identified. Aims. This study is aimed at determining the association of XRCC3 Thr241Met (rs861539), XRCC4 G(-1394) T (rs6869366) DNA repair and BAX G(-248) A (rs4645878), and BCL2 C(-938) A (rs2279115) apoptotic gene polymorphisms with breast cancer. Materials and Methods. Genetic analysis was performed using peripheral blood samples. Gene polymorphisms were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. 175 patients and 158 healthy controls were enrolled in the study. Results. Breast cancer risk was 5.43 times more in individuals with AA genotype of Bax G(-248) A (rs4645878) (P=0.002). The risk of metastasis was 11 times with this genotype. It was associated with 6 times more risk of having a tumor larger than 2 cm. The risk of breast cancer was 2.77 times more in individuals carrying the Met/Met genotype of XRCC3 Thr241Met (rs861539) (P=0.009). The risk of having advanced clinical stage (stage III+IV) with the Met/Met genotype was 4 times more increased. No relationship with breast cancer was found with XRCC4 G(-1394) T (rs6869366) and BCL2 C(-938) A (rs2279115) gene polymorphisms. Conclusion. Multicenter trials using subjects with genetic variations are needed to establish the relationship between breast cancer and single gene polymorphism.http://dx.doi.org/10.1155/2022/5817841 |
| spellingShingle | Emre Ozoran Fadime Didem Can Trabulus Duygu Erhan Bahadir Batar Mehmet Guven Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer International Journal of Breast Cancer |
| title | Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer |
| title_full | Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer |
| title_fullStr | Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer |
| title_full_unstemmed | Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer |
| title_short | Association of XRCC3, XRCC4, BAX, and BCL-2 Polymorphisms with the Risk of Breast Cancer |
| title_sort | association of xrcc3 xrcc4 bax and bcl 2 polymorphisms with the risk of breast cancer |
| url | http://dx.doi.org/10.1155/2022/5817841 |
| work_keys_str_mv | AT emreozoran associationofxrcc3xrcc4baxandbcl2polymorphismswiththeriskofbreastcancer AT fadimedidemcantrabulus associationofxrcc3xrcc4baxandbcl2polymorphismswiththeriskofbreastcancer AT duyguerhan associationofxrcc3xrcc4baxandbcl2polymorphismswiththeriskofbreastcancer AT bahadirbatar associationofxrcc3xrcc4baxandbcl2polymorphismswiththeriskofbreastcancer AT mehmetguven associationofxrcc3xrcc4baxandbcl2polymorphismswiththeriskofbreastcancer |