Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients
Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients’ reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional...
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/2065383 |
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| author | Sanja Dragasevic Aleksandra Sokic-Milutinovic Milica Stojkovic Lalosevic Tamara Milovanovic Srdjan Djuranovic Ivan Jovanovic Sanja Rajic Mirjana Stojkovic Biljana Milicic Stefan Kmezic Branislav Oluic Marko Aleksic Aleksandra Pavlovic Markovic Dragan Popovic |
| author_facet | Sanja Dragasevic Aleksandra Sokic-Milutinovic Milica Stojkovic Lalosevic Tamara Milovanovic Srdjan Djuranovic Ivan Jovanovic Sanja Rajic Mirjana Stojkovic Biljana Milicic Stefan Kmezic Branislav Oluic Marko Aleksic Aleksandra Pavlovic Markovic Dragan Popovic |
| author_sort | Sanja Dragasevic |
| collection | DOAJ |
| description | Background and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients’ reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn’s disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn’s disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn’s disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn’s disease (rs=−0.67; rs=−0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn’s disease. |
| format | Article |
| id | doaj-art-b6a30d5821b24d8aae99803bdf69bf6a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b6a30d5821b24d8aae99803bdf69bf6a2025-02-03T06:46:36ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/20653832065383Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease PatientsSanja Dragasevic0Aleksandra Sokic-Milutinovic1Milica Stojkovic Lalosevic2Tamara Milovanovic3Srdjan Djuranovic4Ivan Jovanovic5Sanja Rajic6Mirjana Stojkovic7Biljana Milicic8Stefan Kmezic9Branislav Oluic10Marko Aleksic11Aleksandra Pavlovic Markovic12Dragan Popovic13Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaInstitute for Medical Informatics, University of Belgrade, School of Dentistry, Rankeova 4, Belgrade, SerbiaSchool of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, SerbiaSchool of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, SerbiaInstitute for Orthopedic Surgery “Banjica”, 28 Mihaila Avramovića Street, Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaClinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, SerbiaBackground and Objectives. Determination of inflammatory bowel disease activity determines further therapeutic approach and follow-up. The aim of our study was to investigate correlation between patients’ reported symptoms and endoscopic and histological disease activity. Methods. A cross-sectional study was conducted in consecutive newly diagnosed patients with inflammatory bowel disease in a tertiary care referral center. The initial evaluation included patient-reported outcome for stool frequency subscore and rectal bleeding. Endoscopic activity was determined using the Mayo scoring system for ulcerative colitis and the Simple Endoscopic Score for Crohn’s disease. Histopathological activity was assessed using a validated numeric scoring system. Results. We included 159 patients (63 Crohn’s disease with colonic involvement and 96 with ulcerative colitis). We found significant correlation between the Mayo endoscopic subscoring system and histology activity in ulcerative colitis, while no correlation was found in patients with Crohn’s disease. Patient-reported outcome showed inverse correlation with endoscopic and histological activity in Crohn’s disease (rs=−0.67; rs=−0.72), while positive correlation was found in ulcerative colitis (rs=0.84; rs=0.75). Interpretation and Conclusions. Patient-reported outcome is a practical and noninvasive tool for assessment of disease activity in ulcerative colitis patients but not in Crohn’s disease.http://dx.doi.org/10.1155/2020/2065383 |
| spellingShingle | Sanja Dragasevic Aleksandra Sokic-Milutinovic Milica Stojkovic Lalosevic Tamara Milovanovic Srdjan Djuranovic Ivan Jovanovic Sanja Rajic Mirjana Stojkovic Biljana Milicic Stefan Kmezic Branislav Oluic Marko Aleksic Aleksandra Pavlovic Markovic Dragan Popovic Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients Gastroenterology Research and Practice |
| title | Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients |
| title_full | Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients |
| title_fullStr | Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients |
| title_full_unstemmed | Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients |
| title_short | Correlation of Patient-Reported Outcome (PRO-2) with Endoscopic and Histological Features in Ulcerative Colitis and Crohn’s Disease Patients |
| title_sort | correlation of patient reported outcome pro 2 with endoscopic and histological features in ulcerative colitis and crohn s disease patients |
| url | http://dx.doi.org/10.1155/2020/2065383 |
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