Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-de...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/1583647 |
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| author | Jiajie Tu Xinming Wang Xun Gong Wenming Hong Dafei Han Yilong Fang Yawei Guo Wei Wei |
| author_facet | Jiajie Tu Xinming Wang Xun Gong Wenming Hong Dafei Han Yilong Fang Yawei Guo Wei Wei |
| author_sort | Jiajie Tu |
| collection | DOAJ |
| description | The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been available to date. In this review, we summarize relevant studies on the two main origins of SMs in rheumatoid arthritis (RA) and forecast the future research directions for this field. Furthermore, we discuss the current state of RA therapy that is based on targeting different SM subsets. |
| format | Article |
| id | doaj-art-b6a2ac4cedb1458c96a6de751ceeffee |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b6a2ac4cedb1458c96a6de751ceeffee2025-02-03T05:44:13ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/15836471583647Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and FutureJiajie Tu0Xinming Wang1Xun Gong2Wenming Hong3Dafei Han4Yilong Fang5Yawei Guo6Wei Wei7Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaThe ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been available to date. In this review, we summarize relevant studies on the two main origins of SMs in rheumatoid arthritis (RA) and forecast the future research directions for this field. Furthermore, we discuss the current state of RA therapy that is based on targeting different SM subsets.http://dx.doi.org/10.1155/2020/1583647 |
| spellingShingle | Jiajie Tu Xinming Wang Xun Gong Wenming Hong Dafei Han Yilong Fang Yawei Guo Wei Wei Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future Mediators of Inflammation |
| title | Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future |
| title_full | Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future |
| title_fullStr | Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future |
| title_full_unstemmed | Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future |
| title_short | Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future |
| title_sort | synovial macrophages in rheumatoid arthritis the past present and future |
| url | http://dx.doi.org/10.1155/2020/1583647 |
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