Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-de...

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Main Authors: Jiajie Tu, Xinming Wang, Xun Gong, Wenming Hong, Dafei Han, Yilong Fang, Yawei Guo, Wei Wei
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2020/1583647
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author Jiajie Tu
Xinming Wang
Xun Gong
Wenming Hong
Dafei Han
Yilong Fang
Yawei Guo
Wei Wei
author_facet Jiajie Tu
Xinming Wang
Xun Gong
Wenming Hong
Dafei Han
Yilong Fang
Yawei Guo
Wei Wei
author_sort Jiajie Tu
collection DOAJ
description The ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been available to date. In this review, we summarize relevant studies on the two main origins of SMs in rheumatoid arthritis (RA) and forecast the future research directions for this field. Furthermore, we discuss the current state of RA therapy that is based on targeting different SM subsets.
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issn 0962-9351
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publishDate 2020-01-01
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series Mediators of Inflammation
spelling doaj-art-b6a2ac4cedb1458c96a6de751ceeffee2025-02-03T05:44:13ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/15836471583647Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and FutureJiajie Tu0Xinming Wang1Xun Gong2Wenming Hong3Dafei Han4Yilong Fang5Yawei Guo6Wei Wei7Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaInstitute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, ChinaThe ontogeny of macrophages in most organs has already been established. Owing to the limited number and inaccessibility of synovial macrophages (SMs), the origin of SMs has not been fully elucidated. Previous studies suggested that SMs have two major origins, namely, tissue-resident and monocyte-derived SMs. However, no systematic analysis to identify SM ontology in either physiological or pathological conditions has been available to date. In this review, we summarize relevant studies on the two main origins of SMs in rheumatoid arthritis (RA) and forecast the future research directions for this field. Furthermore, we discuss the current state of RA therapy that is based on targeting different SM subsets.http://dx.doi.org/10.1155/2020/1583647
spellingShingle Jiajie Tu
Xinming Wang
Xun Gong
Wenming Hong
Dafei Han
Yilong Fang
Yawei Guo
Wei Wei
Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
Mediators of Inflammation
title Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
title_full Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
title_fullStr Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
title_full_unstemmed Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
title_short Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future
title_sort synovial macrophages in rheumatoid arthritis the past present and future
url http://dx.doi.org/10.1155/2020/1583647
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