Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients
Objective. This study evaluated the long-term effects and clinical significance of latent abnormal pathology on elder living donor kidney graft function after renal transplantation in China. Methods. One-hundred and thirty-eight living donor renal transplantations have been carried out at our hospit...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/605704 |
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| author | Linlin Ma Lei Zhang Yu Du Zelin Xie Yawang Tang Jun Lin Wen Sun Hongbo Guo Rumei Bi Mengmeng Zhang Xi Zhu Ye Tian |
| author_facet | Linlin Ma Lei Zhang Yu Du Zelin Xie Yawang Tang Jun Lin Wen Sun Hongbo Guo Rumei Bi Mengmeng Zhang Xi Zhu Ye Tian |
| author_sort | Linlin Ma |
| collection | DOAJ |
| description | Objective. This study evaluated the long-term effects and clinical significance of latent abnormal pathology on elder living donor kidney graft function after renal transplantation in China. Methods. One-hundred and thirty-eight living donor renal transplantations have been carried out at our hospital in recent years. Of these, 72 Time-Zero biopsies were performed and used in this analysis. Clinical data were retrospectively measured at 3, 6, 12, and 24 months after renal transplants. Relationships and effects from biopsy results taken from implanted donor kidney grafts were analyzed. Results. Time-Zero biopsy pathology results from donor kidneys showed that 48.61% of donor kidneys had latent abnormal changes; arterial lesions of donor kidneys had significant effects on the renal function of grafts after 2 years' transplantation; correlations between donor age and arterial lesions were significant; and Time-Zero biopsy pathology results could help predict the long-term function of a renal graft. Conclusions. Existing latent pathological changes of an elder living donor kidney before transplantation could affect long-term renal function. Whether a senior donor is used should be very carefully considered. |
| format | Article |
| id | doaj-art-b69c0fae44e240ed871162842cae68ee |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-b69c0fae44e240ed871162842cae68ee2025-02-03T01:12:08ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/605704605704Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft RecipientsLinlin Ma0Lei Zhang1Yu Du2Zelin Xie3Yawang Tang4Jun Lin5Wen Sun6Hongbo Guo7Rumei Bi8Mengmeng Zhang9Xi Zhu10Ye Tian11Urology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaUrology Surgery Department, Beijing Friendship Hospital-Affiliated Capital Medical University, Beijing 100050, ChinaObjective. This study evaluated the long-term effects and clinical significance of latent abnormal pathology on elder living donor kidney graft function after renal transplantation in China. Methods. One-hundred and thirty-eight living donor renal transplantations have been carried out at our hospital in recent years. Of these, 72 Time-Zero biopsies were performed and used in this analysis. Clinical data were retrospectively measured at 3, 6, 12, and 24 months after renal transplants. Relationships and effects from biopsy results taken from implanted donor kidney grafts were analyzed. Results. Time-Zero biopsy pathology results from donor kidneys showed that 48.61% of donor kidneys had latent abnormal changes; arterial lesions of donor kidneys had significant effects on the renal function of grafts after 2 years' transplantation; correlations between donor age and arterial lesions were significant; and Time-Zero biopsy pathology results could help predict the long-term function of a renal graft. Conclusions. Existing latent pathological changes of an elder living donor kidney before transplantation could affect long-term renal function. Whether a senior donor is used should be very carefully considered.http://dx.doi.org/10.1155/2013/605704 |
| spellingShingle | Linlin Ma Lei Zhang Yu Du Zelin Xie Yawang Tang Jun Lin Wen Sun Hongbo Guo Rumei Bi Mengmeng Zhang Xi Zhu Ye Tian Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients Clinical and Developmental Immunology |
| title | Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients |
| title_full | Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients |
| title_fullStr | Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients |
| title_full_unstemmed | Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients |
| title_short | Latent Abnormal Pathology Affects Long-Term Graft Function in Elder Living Renal Allograft Recipients |
| title_sort | latent abnormal pathology affects long term graft function in elder living renal allograft recipients |
| url | http://dx.doi.org/10.1155/2013/605704 |
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