Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age
The objective of the present study was to evaluate the influence of second-trimester ultrasound markers on the incidence of Down syndrome among pregnant women of advanced maternal age. This was a retrospective cohort study on 889 singleton pregnancies between the 14th and 30th weeks, with maternal a...
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Wiley
2014-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2014/785730 |
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| author | Mariza Rumi Kataguiri Edward Araujo Júnior Luiz Claudio Silva Bussamra Luciano Marcondes Machado Nardozza Antonio Fernandes Moron |
| author_facet | Mariza Rumi Kataguiri Edward Araujo Júnior Luiz Claudio Silva Bussamra Luciano Marcondes Machado Nardozza Antonio Fernandes Moron |
| author_sort | Mariza Rumi Kataguiri |
| collection | DOAJ |
| description | The objective of the present study was to evaluate the influence of second-trimester ultrasound markers on the incidence of Down syndrome among pregnant women of advanced maternal age. This was a retrospective cohort study on 889 singleton pregnancies between the 14th and 30th weeks, with maternal age ≥ 35 years, which would undergo genetic amniocentesis. The second-trimester ultrasound assessed the following markers: increased nuchal fold thickness, cardiac hyperechogenic focus, mild ventriculomegaly, choroid plexus cysts, uni- or bilateral renal pyelectasis, intestinal hyperechogenicity, single umbilical artery, short femur and humerus length, hand/foot alterations, structural fetal malformation, and congenital heart disease. To investigate differences between the groups with and without markers, nonparametric tests consisting of the chi-square test or Fisher’s exact test were used. Moreover, odds ratios with their respective 95% confidence intervals were calculated. Out of the 889 pregnant women, 131 (17.3%) presented markers and 758 (82.7%) did not present markers on the second-trimester ultrasound. Increased nuchal fold (P<0.001) and structural malformation (P<0.001) were the markers most associated with Down syndrome. The presence of one marker increased the relative risk 10.5-fold, while the presence of two or more markers increased the risk 13.5-fold. The presence of markers on the second-trimester ultrasound, especially thickened nuchal fold and structural malformation, increased the risk of Down syndrome among pregnant women with advanced maternal age. |
| format | Article |
| id | doaj-art-b681c871faba495d841f1feffcf97221 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-b681c871faba495d841f1feffcf972212025-02-03T01:27:27ZengWileyJournal of Pregnancy2090-27272090-27352014-01-01201410.1155/2014/785730785730Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal AgeMariza Rumi Kataguiri0Edward Araujo Júnior1Luiz Claudio Silva Bussamra2Luciano Marcondes Machado Nardozza3Antonio Fernandes Moron4Department of Obstetrics, Paulista School of Medicine—Federal University of São Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 São Paulo, BrazilDepartment of Obstetrics, Paulista School of Medicine—Federal University of São Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 São Paulo, BrazilDepartment of Obstetrics, Paulista School of Medicine—Federal University of São Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 São Paulo, BrazilDepartment of Obstetrics, Paulista School of Medicine—Federal University of São Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 São Paulo, BrazilDepartment of Obstetrics, Paulista School of Medicine—Federal University of São Paulo (EPM-UNIFESP), Rua Carlos Weber, 956, apto. 113 Visage, Vila Leopoldina, 05303-000 São Paulo, BrazilThe objective of the present study was to evaluate the influence of second-trimester ultrasound markers on the incidence of Down syndrome among pregnant women of advanced maternal age. This was a retrospective cohort study on 889 singleton pregnancies between the 14th and 30th weeks, with maternal age ≥ 35 years, which would undergo genetic amniocentesis. The second-trimester ultrasound assessed the following markers: increased nuchal fold thickness, cardiac hyperechogenic focus, mild ventriculomegaly, choroid plexus cysts, uni- or bilateral renal pyelectasis, intestinal hyperechogenicity, single umbilical artery, short femur and humerus length, hand/foot alterations, structural fetal malformation, and congenital heart disease. To investigate differences between the groups with and without markers, nonparametric tests consisting of the chi-square test or Fisher’s exact test were used. Moreover, odds ratios with their respective 95% confidence intervals were calculated. Out of the 889 pregnant women, 131 (17.3%) presented markers and 758 (82.7%) did not present markers on the second-trimester ultrasound. Increased nuchal fold (P<0.001) and structural malformation (P<0.001) were the markers most associated with Down syndrome. The presence of one marker increased the relative risk 10.5-fold, while the presence of two or more markers increased the risk 13.5-fold. The presence of markers on the second-trimester ultrasound, especially thickened nuchal fold and structural malformation, increased the risk of Down syndrome among pregnant women with advanced maternal age.http://dx.doi.org/10.1155/2014/785730 |
| spellingShingle | Mariza Rumi Kataguiri Edward Araujo Júnior Luiz Claudio Silva Bussamra Luciano Marcondes Machado Nardozza Antonio Fernandes Moron Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age Journal of Pregnancy |
| title | Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age |
| title_full | Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age |
| title_fullStr | Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age |
| title_full_unstemmed | Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age |
| title_short | Influence of Second-Trimester Ultrasound Markers for Down Syndrome in Pregnant Women of Advanced Maternal Age |
| title_sort | influence of second trimester ultrasound markers for down syndrome in pregnant women of advanced maternal age |
| url | http://dx.doi.org/10.1155/2014/785730 |
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