Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study
Background The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be a potential biomarker of neuropsychiatric involvement in SLE (NPSLE).Methods 80 patients with SLE were included.We obtained paired serum and CSF samples from 48 patients (NPSLE...
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BMJ Publishing Group
2025-01-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/12/1/e001309.full |
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| author | Karel Pavelka Marta Olejárova Veronika Balajková Aneta Prokopcová Martin Elisak Hana Mojžišová |
| author_facet | Karel Pavelka Marta Olejárova Veronika Balajková Aneta Prokopcová Martin Elisak Hana Mojžišová |
| author_sort | Karel Pavelka |
| collection | DOAJ |
| description | Background The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be a potential biomarker of neuropsychiatric involvement in SLE (NPSLE).Methods 80 patients with SLE were included.We obtained paired serum and CSF samples from 48 patients (NPSLE n=32, non-NPSLE n=16) and 31 controls. The serum and CSF levels of NfL were determined using ELISA.Results Patients with NPSLE demonstrated significantly higher levels of serum NfL compared with the non-NPSLE group (mean 31.68±36.63 pg/mL vs mean 16.75±12.48 pg/mL, respectively, p<0.05) and with controls (mean 10.74±4.36 pg/mL, p<0.01). Notably, CSF NfL concentrations in patients with NPSLE showed an upward trend (mean 1600±2852 pg/mL) in contrast to non-NPSLE patients (mean 393.4±191.9 pg/mL) and controls (mean 509.7±358.5 pg/mL). Furthermore, a positive correlation was observed between serum and CSF NfL levels in patients with NPSLE (R=0.8686, p<0.01). Elevated serum triacylglycerol concentrations, C reactive protein and organ damage were linked to increased serum (p=0.002; p<0.001; p=0.036) and CSF (p=0.008; p=0.007; p<0.001) NfL concentrations. In addition, we established a significant correlation between intrathecal NfL concentrations and interleukin-6 levels in the CSF of patients with NPSLE (R=0.5118, p<0.05).Conclusion The serum NfL levels may be a readily available marker of neuropsychiatric involvement in SLE. |
| format | Article |
| id | doaj-art-b67e8dd3fff84ce3b4080aaede49d961 |
| institution | Kabale University |
| issn | 2053-8790 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMJ Publishing Group |
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| series | Lupus Science and Medicine |
| spelling | doaj-art-b67e8dd3fff84ce3b4080aaede49d9612025-01-21T11:55:10ZengBMJ Publishing GroupLupus Science and Medicine2053-87902025-01-0112110.1136/lupus-2024-001309Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional studyKarel Pavelka0Marta Olejárova1Veronika Balajková2Aneta Prokopcová3Martin Elisak4Hana Mojžišová5Institute of Rheumatology, Prague 2, Czech RepublicInstitute of Rheumatology, Prague 2, Czech RepublicInstitute of Rheumatology, Prague 2, Czech RepublicInstitute of Rheumatology, Prague 2, Czech RepublicDepartment of Neurology, Charles University, Prague, Czech RepublicDepartment of Neurology, Charles University, Prague, Czech RepublicBackground The neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum as a marker of neuronal damage may be a potential biomarker of neuropsychiatric involvement in SLE (NPSLE).Methods 80 patients with SLE were included.We obtained paired serum and CSF samples from 48 patients (NPSLE n=32, non-NPSLE n=16) and 31 controls. The serum and CSF levels of NfL were determined using ELISA.Results Patients with NPSLE demonstrated significantly higher levels of serum NfL compared with the non-NPSLE group (mean 31.68±36.63 pg/mL vs mean 16.75±12.48 pg/mL, respectively, p<0.05) and with controls (mean 10.74±4.36 pg/mL, p<0.01). Notably, CSF NfL concentrations in patients with NPSLE showed an upward trend (mean 1600±2852 pg/mL) in contrast to non-NPSLE patients (mean 393.4±191.9 pg/mL) and controls (mean 509.7±358.5 pg/mL). Furthermore, a positive correlation was observed between serum and CSF NfL levels in patients with NPSLE (R=0.8686, p<0.01). Elevated serum triacylglycerol concentrations, C reactive protein and organ damage were linked to increased serum (p=0.002; p<0.001; p=0.036) and CSF (p=0.008; p=0.007; p<0.001) NfL concentrations. In addition, we established a significant correlation between intrathecal NfL concentrations and interleukin-6 levels in the CSF of patients with NPSLE (R=0.5118, p<0.05).Conclusion The serum NfL levels may be a readily available marker of neuropsychiatric involvement in SLE.https://lupus.bmj.com/content/12/1/e001309.full |
| spellingShingle | Karel Pavelka Marta Olejárova Veronika Balajková Aneta Prokopcová Martin Elisak Hana Mojžišová Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study Lupus Science and Medicine |
| title | Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study |
| title_full | Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study |
| title_fullStr | Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study |
| title_full_unstemmed | Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study |
| title_short | Elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus: a cross-sectional study |
| title_sort | elevated serum neurofilament light chain levels in patients with neuropsychiatric systemic lupus erythematosus a cross sectional study |
| url | https://lupus.bmj.com/content/12/1/e001309.full |
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