Mitigation of learning and memory impairment caused by acute total sleep deprivation through OX1R/OX2R-mediated hippocampal neurogenesis in rats

Mitigation of learning and memory impairment caused by acute total sleep deprivation through OX1R/OX2R-mediated hippocampal neurogenesis in rats

Sleep deprivation (SD) impairs learning and memory, which may be correlated with hippocampal neurogenesis. To observe the effects on learning and memory and hippocampal neurogenesis in the hippocampal CA1 area, we first transfected lentivirus to downregulate orexin receptor function in rats. Then, w...

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Bibliographic Details
Main Authors: Yixin Yu, Na Shao, Xiao Zhang, Wanyu Zhao, Baokun Zhang, Jiyou Tang, Shi Tang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Experimental Gerontology
Subjects:
Learning and memory
Sleep deprivation
Orexin receptor
Neurogenesis
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556525000981
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