Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation
Immunocompromised patients, including hematopoietic stem cell transplantation (HSCT), HIV, and malnourished patients, are at increased risk for viral infections with high incidences of morbidity and mortality. In HSCT patients, the infection risk is increased until immune reconstitution is re-establ...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2020/5981289 |
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| _version_ | 1832560690459574272 |
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| author | T. Van Genechten J. van Heerden T. Bauters C. Dhooge |
| author_facet | T. Van Genechten J. van Heerden T. Bauters C. Dhooge |
| author_sort | T. Van Genechten |
| collection | DOAJ |
| description | Immunocompromised patients, including hematopoietic stem cell transplantation (HSCT), HIV, and malnourished patients, are at increased risk for viral infections with high incidences of morbidity and mortality. In HSCT patients, the infection risk is increased until immune reconstitution is re-established. Therapy with standard of care antiviral drugs, for example Cidofovir, is expensive, requires prolonged administration, and has unfavorable toxicity profiles. Our case describes the successful use of Brincidofovir (CMX001), a lipid-conjugate of the nucleotide analog Cidofovir, in a 9-year-old post-HSCT girl with disseminated adenovirus infection. The increased efficacy of Brincidofovir (BCV) against multiple viral infections, limited toxicity, and oral-administered schedule opens options in different resource settings. |
| format | Article |
| id | doaj-art-b6668b357b574e5e88347ff500a49f74 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-b6668b357b574e5e88347ff500a49f742025-02-03T01:26:56ZengWileyCase Reports in Infectious Diseases2090-66252090-66332020-01-01202010.1155/2020/59812895981289Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell TransplantationT. Van Genechten0J. van Heerden1T. Bauters2C. Dhooge3Pediatric Haematology Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, BelgiumPediatric Haematology and Oncology Department, Antwerp University Hospital, Antwerp, BelgiumPediatric Haematology Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, BelgiumPediatric Haematology Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, BelgiumImmunocompromised patients, including hematopoietic stem cell transplantation (HSCT), HIV, and malnourished patients, are at increased risk for viral infections with high incidences of morbidity and mortality. In HSCT patients, the infection risk is increased until immune reconstitution is re-established. Therapy with standard of care antiviral drugs, for example Cidofovir, is expensive, requires prolonged administration, and has unfavorable toxicity profiles. Our case describes the successful use of Brincidofovir (CMX001), a lipid-conjugate of the nucleotide analog Cidofovir, in a 9-year-old post-HSCT girl with disseminated adenovirus infection. The increased efficacy of Brincidofovir (BCV) against multiple viral infections, limited toxicity, and oral-administered schedule opens options in different resource settings.http://dx.doi.org/10.1155/2020/5981289 |
| spellingShingle | T. Van Genechten J. van Heerden T. Bauters C. Dhooge Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation Case Reports in Infectious Diseases |
| title | Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation |
| title_full | Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation |
| title_fullStr | Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation |
| title_full_unstemmed | Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation |
| title_short | Successful Treatment of Adenovirus Infection with Brincidofovir in an Immunocompromised Patient after Hematological Stem Cell Transplantation |
| title_sort | successful treatment of adenovirus infection with brincidofovir in an immunocompromised patient after hematological stem cell transplantation |
| url | http://dx.doi.org/10.1155/2020/5981289 |
| work_keys_str_mv | AT tvangenechten successfultreatmentofadenovirusinfectionwithbrincidofovirinanimmunocompromisedpatientafterhematologicalstemcelltransplantation AT jvanheerden successfultreatmentofadenovirusinfectionwithbrincidofovirinanimmunocompromisedpatientafterhematologicalstemcelltransplantation AT tbauters successfultreatmentofadenovirusinfectionwithbrincidofovirinanimmunocompromisedpatientafterhematologicalstemcelltransplantation AT cdhooge successfultreatmentofadenovirusinfectionwithbrincidofovirinanimmunocompromisedpatientafterhematologicalstemcelltransplantation |