Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm
Abstract Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by localized dilation of the abdominal aorta, posing a significant risk of rupture and fatal hemorrhage. While surgical and endovascular repair techniques have advanced, the underlying mechanisms driving AAA devel...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | European Journal of Medical Research |
| Online Access: | https://doi.org/10.1186/s40001-024-02128-4 |
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| author | Han Wang Zhihai Xu Jing Guo Lei Li Yu Tian Shengjie Fu |
| author_facet | Han Wang Zhihai Xu Jing Guo Lei Li Yu Tian Shengjie Fu |
| author_sort | Han Wang |
| collection | DOAJ |
| description | Abstract Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by localized dilation of the abdominal aorta, posing a significant risk of rupture and fatal hemorrhage. While surgical and endovascular repair techniques have advanced, the underlying mechanisms driving AAA development remain unclear, hindering the development of effective preventive and therapeutic strategies. Using bioinformatics analysis of publicly available data sets, the study identified a strong correlation between cell death (CD) score and different types of programmed cell death scores in AAA samples. WGCNA analysis revealed a module enriched in genes related to proteasome-mediated protein degradation, nuclear envelope, and endocytosis, significantly correlated with CD score. Further analysis identified ABI1 as a dominant feature gene, highlighting its potential role in AAA pathogenesis. In vitro validation using an Angiotensin II-induced AAA model in human aortic smooth muscle cells demonstrated that siRNA-mediated knockdown of ABI1 significantly reduced cell apoptosis, migration, and the expression of pro-apoptotic proteins, confirming ABI1's crucial role in promoting CD and AAA progression. The findings suggest that ABI1 may represent a promising therapeutic target for the prevention and treatment of AAA. Further research is warranted to fully understand the role of ABI1 in AAA and to develop targeted therapies based on this promising target. |
| format | Article |
| id | doaj-art-b663ae051d69427a9ffcd83473b26235 |
| institution | OA Journals |
| issn | 2047-783X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-b663ae051d69427a9ffcd83473b262352025-08-20T02:22:24ZengBMCEuropean Journal of Medical Research2047-783X2024-11-0129111210.1186/s40001-024-02128-4Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysmHan Wang0Zhihai Xu1Jing Guo2Lei Li3Yu Tian4Shengjie Fu5Department of Vascular Surgery, The Second Hospital of Dalian Medical UniversityDepartment of Vascular Surgery, The Second Hospital of Dalian Medical UniversityDepartment of Emergency, The Second Hospital of Dalian Medical UniversityDepartment of Vascular Surgery, The Second Hospital of Dalian Medical UniversityDepartment of Vascular Surgery, The Second Hospital of Dalian Medical UniversityDepartment of Vascular Surgery, The Second Hospital of Dalian Medical UniversityAbstract Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by localized dilation of the abdominal aorta, posing a significant risk of rupture and fatal hemorrhage. While surgical and endovascular repair techniques have advanced, the underlying mechanisms driving AAA development remain unclear, hindering the development of effective preventive and therapeutic strategies. Using bioinformatics analysis of publicly available data sets, the study identified a strong correlation between cell death (CD) score and different types of programmed cell death scores in AAA samples. WGCNA analysis revealed a module enriched in genes related to proteasome-mediated protein degradation, nuclear envelope, and endocytosis, significantly correlated with CD score. Further analysis identified ABI1 as a dominant feature gene, highlighting its potential role in AAA pathogenesis. In vitro validation using an Angiotensin II-induced AAA model in human aortic smooth muscle cells demonstrated that siRNA-mediated knockdown of ABI1 significantly reduced cell apoptosis, migration, and the expression of pro-apoptotic proteins, confirming ABI1's crucial role in promoting CD and AAA progression. The findings suggest that ABI1 may represent a promising therapeutic target for the prevention and treatment of AAA. Further research is warranted to fully understand the role of ABI1 in AAA and to develop targeted therapies based on this promising target.https://doi.org/10.1186/s40001-024-02128-4 |
| spellingShingle | Han Wang Zhihai Xu Jing Guo Lei Li Yu Tian Shengjie Fu Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm European Journal of Medical Research |
| title | Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm |
| title_full | Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm |
| title_fullStr | Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm |
| title_full_unstemmed | Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm |
| title_short | Programmed cell death-related ABI1 is a critical mediator of abdominal aortic aneurysm |
| title_sort | programmed cell death related abi1 is a critical mediator of abdominal aortic aneurysm |
| url | https://doi.org/10.1186/s40001-024-02128-4 |
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