The Role of Interleukin-17 in Lung Cancer
Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associat...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/8494079 |
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| _version_ | 1850160274293653504 |
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| author | Feng Wu Juanjuan Xu Qi Huang Jieli Han Limin Duan Jinshuo Fan Zhilei Lv Mengfei Guo Guorong Hu Lian Chen Shuai Zhang Xiaonan Tao Wanli Ma Yang Jin |
| author_facet | Feng Wu Juanjuan Xu Qi Huang Jieli Han Limin Duan Jinshuo Fan Zhilei Lv Mengfei Guo Guorong Hu Lian Chen Shuai Zhang Xiaonan Tao Wanli Ma Yang Jin |
| author_sort | Feng Wu |
| collection | DOAJ |
| description | Tumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways. Therefore, IL-17 contributes to the metastasis and progression of lung cancer. Research advances with respect to the role of IL-17 in lung cancer will be presented as a review in this paper. |
| format | Article |
| id | doaj-art-b662494de11d450a81dc89b00dad94d4 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b662494de11d450a81dc89b00dad94d42025-08-20T02:23:11ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/84940798494079The Role of Interleukin-17 in Lung CancerFeng Wu0Juanjuan Xu1Qi Huang2Jieli Han3Limin Duan4Jinshuo Fan5Zhilei Lv6Mengfei Guo7Guorong Hu8Lian Chen9Shuai Zhang10Xiaonan Tao11Wanli Ma12Yang Jin13Key Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaKey Laboratory of Respiratory Diseases, Ministry of Health, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, ChinaTumour-associated inflammation is a hallmark of malignant carcinomas, and lung cancer is a typical inflammation-associated carcinoma. Interleukin-17 (IL-17) is an important inflammatory cytokine that plays an important role in chronic inflammatory and autoimmune diseases and in inflammation-associated tumours. Numerous studies have shown that IL-17 directly or indirectly promotes tumour angiogenesis and cell proliferation and that it inhibits apoptosis via the activation of inflammatory signalling pathways. Therefore, IL-17 contributes to the metastasis and progression of lung cancer. Research advances with respect to the role of IL-17 in lung cancer will be presented as a review in this paper.http://dx.doi.org/10.1155/2016/8494079 |
| spellingShingle | Feng Wu Juanjuan Xu Qi Huang Jieli Han Limin Duan Jinshuo Fan Zhilei Lv Mengfei Guo Guorong Hu Lian Chen Shuai Zhang Xiaonan Tao Wanli Ma Yang Jin The Role of Interleukin-17 in Lung Cancer Mediators of Inflammation |
| title | The Role of Interleukin-17 in Lung Cancer |
| title_full | The Role of Interleukin-17 in Lung Cancer |
| title_fullStr | The Role of Interleukin-17 in Lung Cancer |
| title_full_unstemmed | The Role of Interleukin-17 in Lung Cancer |
| title_short | The Role of Interleukin-17 in Lung Cancer |
| title_sort | role of interleukin 17 in lung cancer |
| url | http://dx.doi.org/10.1155/2016/8494079 |
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