Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy
The present report describes the case of a 56-year-old African American man experiencing progressive disequilibrium, lower extremity weakness, difficulty walking, and hearing loss. Brain magnetic resonance imaging showed leptomeningeal enhancement. Initial differential diagnosis was broad, including...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/9513576 |
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| author | Sahara N. Saltijeral Horiana B. Grosu Henriette De La Garza Barbara O’Brien Gloria Iliescu |
| author_facet | Sahara N. Saltijeral Horiana B. Grosu Henriette De La Garza Barbara O’Brien Gloria Iliescu |
| author_sort | Sahara N. Saltijeral |
| collection | DOAJ |
| description | The present report describes the case of a 56-year-old African American man experiencing progressive disequilibrium, lower extremity weakness, difficulty walking, and hearing loss. Brain magnetic resonance imaging showed leptomeningeal enhancement. Initial differential diagnosis was broad, including malignant, infectious, and inflammatory etiologies. The cerebrospinal fluid analyses demonstrated lymphocytic pleocytosis, hypoglycorrhachia, and hyperproteinorrachia but no other abnormalities. An extensive infectious disease workup was negative. Positron emission tomography revealed hypermetabolic lymph nodes in the right mediastinum and right hilum, correlating with findings on endobronchial ultrasonography. Subsequently, image-guided fine-needle aspiration of the right upper paratracheal lymph node was performed, and biopsy studies showed noncaseating granulomatous inflammation. Based on the clinical picture, the diagnosis of neurosarcoidosis was made, and high-dose steroids were started and resulted in significant improvement. |
| format | Article |
| id | doaj-art-b65510f362af4d7497651ed26656f5ca |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b65510f362af4d7497651ed26656f5ca2025-02-03T06:46:07ZengWileyCase Reports in Medicine1687-96271687-96352020-01-01202010.1155/2020/95135769513576Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking MalignancySahara N. Saltijeral0Horiana B. Grosu1Henriette De La Garza2Barbara O’Brien3Gloria Iliescu4Departments of Internal Medicine, Instituto Tecnologico y de Estudios Superiores de Monterrey, Monterrey, MexicoDepartments of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USADepartments of Internal Medicine, Instituto Tecnologico y de Estudios Superiores de Monterrey, Monterrey, MexicoDepartments of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAInternal Medicine The University of Texas MD Anderson Cancer Center, Houston, TX, USAThe present report describes the case of a 56-year-old African American man experiencing progressive disequilibrium, lower extremity weakness, difficulty walking, and hearing loss. Brain magnetic resonance imaging showed leptomeningeal enhancement. Initial differential diagnosis was broad, including malignant, infectious, and inflammatory etiologies. The cerebrospinal fluid analyses demonstrated lymphocytic pleocytosis, hypoglycorrhachia, and hyperproteinorrachia but no other abnormalities. An extensive infectious disease workup was negative. Positron emission tomography revealed hypermetabolic lymph nodes in the right mediastinum and right hilum, correlating with findings on endobronchial ultrasonography. Subsequently, image-guided fine-needle aspiration of the right upper paratracheal lymph node was performed, and biopsy studies showed noncaseating granulomatous inflammation. Based on the clinical picture, the diagnosis of neurosarcoidosis was made, and high-dose steroids were started and resulted in significant improvement.http://dx.doi.org/10.1155/2020/9513576 |
| spellingShingle | Sahara N. Saltijeral Horiana B. Grosu Henriette De La Garza Barbara O’Brien Gloria Iliescu Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy Case Reports in Medicine |
| title | Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy |
| title_full | Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy |
| title_fullStr | Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy |
| title_full_unstemmed | Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy |
| title_short | Leptomeningeal Enhancement due to Neurosarcoidosis Mimicking Malignancy |
| title_sort | leptomeningeal enhancement due to neurosarcoidosis mimicking malignancy |
| url | http://dx.doi.org/10.1155/2020/9513576 |
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