From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments

From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments

Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, among which 82% arise from actinic keratosis (AK) characterized by lesions of epidermal keratinocyte dysplasia. It is of great significance to uncover the progression mechanisms from AK to cSCC, which will f...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zhenlin Li, Fangqi Lu, Fujin Zhou, Dekun Song, Lunhui Chang, Weiying Liu, Guorong Yan, Guolong Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Immunology
Subjects:	actinic keratosis cutaneous squamous cell carcinoma progression malignant transformation skin cancers non-melanoma skin cancers
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518633/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Prebiotic- and Panthenol-Containing Multipurpose Healing Dermocosmetics Post-Cryotherapy for Actinic Keratoses: Results of a Randomized Controlled Trial
by: Cesare Ariasi, et al.
Published: (2025-01-01)

Pigmented pathological type and depth of follicular extension as predictors of treatment failure in 5-aminolevulinic acid photodynamic therapy for actinic keratosis: A retrospective, matched nested case-control study
by: Qinyuan Zhu, et al.
Published: (2025-04-01)

Epidemiology and Management of Actinic Keratosis in France: A General Population Survey (REAKT)
by: Brigitte Dréno, et al.
Published: (2025-01-01)

The Skin-Lightening Power of Tirbanibulin 1% Ointment
by: Federica Li Pomi, et al.
Published: (2024-11-01)

Comparative Efficacy and Tolerability of Imiquimod 3.75% Cream vs 5-Fluorouracil 4% cream in the Treatment of Actinic Keratosis: A Split-Face Study
by: Cesare Ariasi, et al.
Published: (2025-01-01)

A scoping review examining the relationship between green tea and skin cancers
by: Ram Lakhan, et al.
Published: (2019-11-01)

Epidemiology of Non-Melanoma Skin Cancer Patients Attending at Hiwa Hospital in Sulaimani City, Iraq
by: Bushra Mohammed Ali, et al.
Published: (2018-07-01)

A study on the global burden of non-melanoma skin cancer from 1990 to 2019
by: Zixiang Si, et al.
Published: (2024-04-01)

Skin in the game: epidemiology analysis of skin cancer in rural Western Victoria
by: Tori Dopheide, et al.
Published: (2025-01-01)

Immunosuppression and Outcomes in Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck
by: Doriana Iancu, et al.
Published: (2025-01-01)

Classification of Melanoma Cancer Using Deep Convolutional Neural Networks
by: Emrah Dönmez, et al.
Published: (2024-12-01)

Advances in the photodynamic treatment of solar keratosis
by: SHEN Haojia, et al.
Published: (2025-01-01)

Effects of Environmental Factors on Nutrients Release at Sediment-Water Interface and Assessment of Trophic Status for a Typical Shallow Lake, Northwest China
by: Dekun Hou, et al.
Published: (2013-01-01)

Skin Tumors Diagnosis Utilizing Case Based Reasoning and The Expert System
by: Roza Fuad Majeed, et al.
Published: (2020-06-01)

Normal and melanoma skin visualized, quantified and compared by in vivo photoacoustic imaging
by: Terese von Knorring, et al.
Published: (2025-04-01)

Keratosis Lichenoides Chronica Successfully Treated With Doxycycline: A Therapeutic Option for a Rare Dermatologic Condition
by: Paula Dall’Oglio Furlan, et al.
Published: (2025-01-01)

Dermoscopy in the Diagnosis of Keratosis Lichenoides Striata (Nekam Disease): A Rare Clinical Entity
by: Caterina Mariarosaria Giorgio, et al.
Published: (2025-01-01)

Prediction of the Stability of the Loaded Rock Based on the Acoustic Emission Characteristics of the Loaded Rock Based on Data Mining
by: Mengyao Li, et al.
Published: (2021-01-01)

Efficacy of PDD-guided tumor excision combined with photodynamic therapy in cutaneous squamous cell carcinoma
by: Nan Yang, et al.
Published: (2025-02-01)

Ankle edema after administration of selective serotonin reuptake inhibitors
by: Konstantinos Kontoangelos, et al.
Published: (2018-06-01)

Synchronous melanomas: one on tattoo and one on healthy skin
by: Francesco Ricci, et al.
Published: (2025-02-01)

Surface mold brachytherapy for head and neck non-melanoma skin cancer – local control rates and survival: A retrospective analysis
by: Ebrahim Esmati, et al.
Published: (2024-10-01)

Automated Diagnosis of Skin Cancer.
by: Nyiramugisha, Shallon, et al.
Published: (2025)

Prevalence and pattern of skin disorders among children living in orphanages in Fayoum and Giza governorates, Egypt
by: Noha Ezzat Mohamed, et al.
Published: (2025-01-01)

A Rare Cutaneous Malignancy: A Primary Cutaneous Carcinosarcoma with Adnexal Epithelial Component (Trichoblastic Carcinosarcoma) of Left Temporal Region
by: Vaishali B. Nagose, et al.
Published: (2024-01-01)

Risk of second primary malignancies among survivors of cutaneous melanoma: A nationwide population-based study in the Republic of Korea
by: Joon Min Jung, et al.
Published: (2025-01-01)

Chaotic Motions of the Duffing-Van der Pol Oscillator with External and Parametric Excitations
by: Liangqiang Zhou, et al.
Published: (2014-01-01)

Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization
by: Li X, et al.
Published: (2025-01-01)

Interleukin‐37 promotes DMBA/TPA skin cancer through SIGIRR‐mediated inhibition of glycolysis in CD103+DC cells
by: Fan‐lian Zeng, et al.
Published: (2023-04-01)

Stability and Bifurcation for a Simply Supported Functionally Graded Material Plate with One-to-One Internal Resonance
by: Dongmei Zhang, et al.
Published: (2014-01-01)

Segmental stiff skin syndrome: a review of the literature and authors’ experiences
by: Bartłomiej Roszkowski, et al.
Published: (2024-11-01)

Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis
by: Linsa Zhou, et al.
Published: (2025-01-01)

Two-step-7-Pink Rule: A Practical Tool for the Dermoscopic Evaluation of Fully Amelanotic Skin Lesions
by: Riccardo Pampena, et al.
Published: (2025-01-01)

Non-convex optimization with using positive-negative moment estimation and its application for skin cancer recognition with a neural network
by: P.A. Lyakhov, et al.
Published: (2024-04-01)

An Enhanced Approach Using AGS Network for Skin Cancer Classification
by: Hwanyoung Lee, et al.
Published: (2025-01-01)

Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice
by: Mengjie Liu, et al.
Published: (2025-01-01)

Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers
by: Gautam Kundu, et al.
Published: (2025-01-01)

Tattoo ink exposure is associated with lymphoma and skin cancers – a Danish study of twins
by: Signe Bedsted Clemmensen, et al.
Published: (2025-01-01)

Automating skin cancer screening: a deep learning
by: Nada M. Rashad, et al.
Published: (2025-01-01)

Effective and safe surgery for keratinocyte skin cancer in the elderly over 80 years of age: a single-institution retrospective study of 345 patients over one year
by: Luca D. Fontana, et al.
Published: (2025-12-01)