From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments
Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, among which 82% arise from actinic keratosis (AK) characterized by lesions of epidermal keratinocyte dysplasia. It is of great significance to uncover the progression mechanisms from AK to cSCC, which will f...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518633/full |
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| author | Zhenlin Li Zhenlin Li Zhenlin Li Zhenlin Li Fangqi Lu Fangqi Lu Fangqi Lu Fangqi Lu Fujin Zhou Fujin Zhou Fujin Zhou Dekun Song Dekun Song Dekun Song Lunhui Chang Lunhui Chang Lunhui Chang Lunhui Chang Weiying Liu Guorong Yan Guorong Yan Guorong Yan Guolong Zhang Guolong Zhang Guolong Zhang Guolong Zhang |
| author_facet | Zhenlin Li Zhenlin Li Zhenlin Li Zhenlin Li Fangqi Lu Fangqi Lu Fangqi Lu Fangqi Lu Fujin Zhou Fujin Zhou Fujin Zhou Dekun Song Dekun Song Dekun Song Lunhui Chang Lunhui Chang Lunhui Chang Lunhui Chang Weiying Liu Guorong Yan Guorong Yan Guorong Yan Guolong Zhang Guolong Zhang Guolong Zhang Guolong Zhang |
| author_sort | Zhenlin Li |
| collection | DOAJ |
| description | Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, among which 82% arise from actinic keratosis (AK) characterized by lesions of epidermal keratinocyte dysplasia. It is of great significance to uncover the progression mechanisms from AK to cSCC, which will facilitate the early therapeutic intervention of AK before malignant transformation. Thus, more and more studies are trying to ascertain the potential transformation mechanisms through multi-omics, including genetics, transcriptomics, and epigenetics. In this review, we gave an overview of the specific biomarkers and signaling pathways that may be involved in the pathogenesis from AK to cSCC, pointing out future possible molecular therapies for the early intervention of AK and cSCC. We also discussed current interventions on AK and cSCC, together with future perspectives. |
| format | Article |
| id | doaj-art-b6550a415cbe401cbdc82bc9353413bd |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b6550a415cbe401cbdc82bc9353413bd2025-01-24T07:13:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15186331518633From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatmentsZhenlin Li0Zhenlin Li1Zhenlin Li2Zhenlin Li3Fangqi Lu4Fangqi Lu5Fangqi Lu6Fangqi Lu7Fujin Zhou8Fujin Zhou9Fujin Zhou10Dekun Song11Dekun Song12Dekun Song13Lunhui Chang14Lunhui Chang15Lunhui Chang16Lunhui Chang17Weiying Liu18Guorong Yan19Guorong Yan20Guorong Yan21Guolong Zhang22Guolong Zhang23Guolong Zhang24Guolong Zhang25School of Medicine, Anhui University of Science and Technology, Huainan, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaInstitute of Photomedicine, School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Anhui University of Science and Technology, Huainan, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaInstitute of Photomedicine, School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Anhui University of Science and Technology, Huainan, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Anhui University of Science and Technology, Huainan, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Anhui University of Science and Technology, Huainan, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaInstitute of Photomedicine, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Dermatology, Hunan Aerospace Hospital, Changsha, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaInstitute of Photomedicine, School of Medicine, Tongji University, Shanghai, ChinaSchool of Medicine, Anhui University of Science and Technology, Huainan, ChinaDepartment of Phototherapy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaSkin Cancer Center, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, ChinaInstitute of Photomedicine, School of Medicine, Tongji University, Shanghai, ChinaCutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, among which 82% arise from actinic keratosis (AK) characterized by lesions of epidermal keratinocyte dysplasia. It is of great significance to uncover the progression mechanisms from AK to cSCC, which will facilitate the early therapeutic intervention of AK before malignant transformation. Thus, more and more studies are trying to ascertain the potential transformation mechanisms through multi-omics, including genetics, transcriptomics, and epigenetics. In this review, we gave an overview of the specific biomarkers and signaling pathways that may be involved in the pathogenesis from AK to cSCC, pointing out future possible molecular therapies for the early intervention of AK and cSCC. We also discussed current interventions on AK and cSCC, together with future perspectives.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518633/fullactinic keratosiscutaneous squamous cell carcinomaprogressionmalignant transformationskin cancersnon-melanoma skin cancers |
| spellingShingle | Zhenlin Li Zhenlin Li Zhenlin Li Zhenlin Li Fangqi Lu Fangqi Lu Fangqi Lu Fangqi Lu Fujin Zhou Fujin Zhou Fujin Zhou Dekun Song Dekun Song Dekun Song Lunhui Chang Lunhui Chang Lunhui Chang Lunhui Chang Weiying Liu Guorong Yan Guorong Yan Guorong Yan Guolong Zhang Guolong Zhang Guolong Zhang Guolong Zhang From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments Frontiers in Immunology actinic keratosis cutaneous squamous cell carcinoma progression malignant transformation skin cancers non-melanoma skin cancers |
| title | From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments |
| title_full | From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments |
| title_fullStr | From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments |
| title_full_unstemmed | From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments |
| title_short | From actinic keratosis to cutaneous squamous cell carcinoma: the key pathogenesis and treatments |
| title_sort | from actinic keratosis to cutaneous squamous cell carcinoma the key pathogenesis and treatments |
| topic | actinic keratosis cutaneous squamous cell carcinoma progression malignant transformation skin cancers non-melanoma skin cancers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1518633/full |
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