Pregnancy and the Biliary System

Alterations in the synthesis and secretion of bile salts and cholesterol and in gallbladder function occur during pregnancy. These changes are related to the effects of estrogen and progesterone. Biliary cholesterol saturation and the cholic acid/chenodeoxycholic acid ratio increase. Progesterone al...

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Main Authors: Helga Witt, J Joseph Connon
Format: Article
Language:English
Published: Wiley 1990-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1990/582650
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author Helga Witt
J Joseph Connon
author_facet Helga Witt
J Joseph Connon
author_sort Helga Witt
collection DOAJ
description Alterations in the synthesis and secretion of bile salts and cholesterol and in gallbladder function occur during pregnancy. These changes are related to the effects of estrogen and progesterone. Biliary cholesterol saturation and the cholic acid/chenodeoxycholic acid ratio increase. Progesterone also diminishes gallbladder contractility and emptying. Gallstones occur in 2.5 to 11% of pregnant women and are associated with cholecystitis in 0.008 to 0.1% of pregnant women. Operative treatment should be deferred if possible until after delivery; failing that, surgery is best done in the second trimester. Endoscopic pap1llotomy may prove to be the best therapy for choledocholithiasis.
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series Canadian Journal of Gastroenterology
spelling doaj-art-b648bb1dfa5b4a55b9748e19dd91f4c12025-02-03T01:24:27ZengWileyCanadian Journal of Gastroenterology0835-79001990-01-014520921410.1155/1990/582650Pregnancy and the Biliary SystemHelga WittJ Joseph ConnonAlterations in the synthesis and secretion of bile salts and cholesterol and in gallbladder function occur during pregnancy. These changes are related to the effects of estrogen and progesterone. Biliary cholesterol saturation and the cholic acid/chenodeoxycholic acid ratio increase. Progesterone also diminishes gallbladder contractility and emptying. Gallstones occur in 2.5 to 11% of pregnant women and are associated with cholecystitis in 0.008 to 0.1% of pregnant women. Operative treatment should be deferred if possible until after delivery; failing that, surgery is best done in the second trimester. Endoscopic pap1llotomy may prove to be the best therapy for choledocholithiasis.http://dx.doi.org/10.1155/1990/582650
spellingShingle Helga Witt
J Joseph Connon
Pregnancy and the Biliary System
Canadian Journal of Gastroenterology
title Pregnancy and the Biliary System
title_full Pregnancy and the Biliary System
title_fullStr Pregnancy and the Biliary System
title_full_unstemmed Pregnancy and the Biliary System
title_short Pregnancy and the Biliary System
title_sort pregnancy and the biliary system
url http://dx.doi.org/10.1155/1990/582650
work_keys_str_mv AT helgawitt pregnancyandthebiliarysystem
AT jjosephconnon pregnancyandthebiliarysystem