Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and dyslipidemia. The abnormalities in nutrient metabolism and elevated inflammatory mediators resulting from DM lead to impairment of wound healing and vulnerability to infection and foot ulcers. Diabetic lower limb ische...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2009/417301 |
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| author | Pei-Hsuan Tsai Jun-Jen Liu Szu-Yuan Chou Yao-Chung Chang Sung-Ling Yeh |
| author_facet | Pei-Hsuan Tsai Jun-Jen Liu Szu-Yuan Chou Yao-Chung Chang Sung-Ling Yeh |
| author_sort | Pei-Hsuan Tsai |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and dyslipidemia. The abnormalities in nutrient metabolism and elevated inflammatory mediators resulting from DM lead to impairment of wound healing and vulnerability to infection and foot ulcers. Diabetic lower limb ischemia often leads to limb necrosis. Lower extremity bypass surgery (LEBS) is indicated to prevent limb loss in patients with critical leg ischemia. This study investigated the alteration of inflammatory and endothelium dysfunction markers before and after LEBS in DM patients. Twenty one type 2 DM patients with LEBS were included. Blood was drawn before and at 1 day and 7 days after surgery in the patients. Plasma soluble cellular adhesion molecule levels and blood leukocyte integrin expressions were measured. Also, plasma concentrations of endothelin-1 and nitric oxide were analyzed to evaluate the vascular endothelial function. The results showed that there were no significant differences in plasma cellular adhesion molecules, endothelin-1 and nitric oxide levels, nor did any differences in leukocyte integrin expressions before and after the operation. These results suggest that the efficacy of LEBS on alleviating inflammatory reaction and improving endothelial function in DM patients was not obvious. |
| format | Article |
| id | doaj-art-b648a2e1440340e18360d69c6010e72d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b648a2e1440340e18360d69c6010e72d2025-02-03T05:49:36ZengWileyMediators of Inflammation0962-93511466-18612009-01-01200910.1155/2009/417301417301Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic PatientsPei-Hsuan Tsai0Jun-Jen Liu1Szu-Yuan Chou2Yao-Chung Chang3Sung-Ling Yeh4School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanSchool of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei 110, TaiwanDepartment of Obstetrics and Gynecology, Taipei Medical University-Associated Wan Fang Hospital, Taipei 116, TaiwanDepartment of General Surgery, Taipei Medical University-Wan Fang Hospital, Taipei 116, TaiwanSchool of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, TaiwanDiabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and dyslipidemia. The abnormalities in nutrient metabolism and elevated inflammatory mediators resulting from DM lead to impairment of wound healing and vulnerability to infection and foot ulcers. Diabetic lower limb ischemia often leads to limb necrosis. Lower extremity bypass surgery (LEBS) is indicated to prevent limb loss in patients with critical leg ischemia. This study investigated the alteration of inflammatory and endothelium dysfunction markers before and after LEBS in DM patients. Twenty one type 2 DM patients with LEBS were included. Blood was drawn before and at 1 day and 7 days after surgery in the patients. Plasma soluble cellular adhesion molecule levels and blood leukocyte integrin expressions were measured. Also, plasma concentrations of endothelin-1 and nitric oxide were analyzed to evaluate the vascular endothelial function. The results showed that there were no significant differences in plasma cellular adhesion molecules, endothelin-1 and nitric oxide levels, nor did any differences in leukocyte integrin expressions before and after the operation. These results suggest that the efficacy of LEBS on alleviating inflammatory reaction and improving endothelial function in DM patients was not obvious.http://dx.doi.org/10.1155/2009/417301 |
| spellingShingle | Pei-Hsuan Tsai Jun-Jen Liu Szu-Yuan Chou Yao-Chung Chang Sung-Ling Yeh Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients Mediators of Inflammation |
| title | Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients |
| title_full | Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients |
| title_fullStr | Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients |
| title_full_unstemmed | Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients |
| title_short | Effect of Lower Extremity Bypass Surgery on Inflammatory Reaction and Endothelial Dysfunction in Type 2 Diabetic Patients |
| title_sort | effect of lower extremity bypass surgery on inflammatory reaction and endothelial dysfunction in type 2 diabetic patients |
| url | http://dx.doi.org/10.1155/2009/417301 |
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