Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis
ABSTRACT Background The risk of sarcopenia in older adults with chronic kidney disease (CKD) not yet on dialysis is controversial. The aims of this study were to investigate the association among sarcopenia, diabetes and predialysis CKD and evaluate the impact of gender and ageing on the risk of sar...
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Wiley
2024-12-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
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| Online Access: | https://doi.org/10.1002/jcsm.13612 |
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| author | Yi‐Fang Huang Shih‐Ping Liu Chih‐Hsin Muo Chen‐Yi Lai Chung‐Ta Chang |
| author_facet | Yi‐Fang Huang Shih‐Ping Liu Chih‐Hsin Muo Chen‐Yi Lai Chung‐Ta Chang |
| author_sort | Yi‐Fang Huang |
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| description | ABSTRACT Background The risk of sarcopenia in older adults with chronic kidney disease (CKD) not yet on dialysis is controversial. The aims of this study were to investigate the association among sarcopenia, diabetes and predialysis CKD and evaluate the impact of gender and ageing on the risk of sarcopenia statuses in older patients with predialysis CKD. Methods The participants aged ≥60 years old were recruited from the community of New Taipei City, Taiwan. Handgrip strength, appendicular skeletal muscle mass and the 6‐m walk were measured. The diagnosis of sarcopenia was established based on the consensus of Asian Sarcopenia Working Group 2019. These older adults were categorised into G1, G2 and G3–5 according to the guidelines of Kidney Disease Improving Global Outcomes (KDIGO) after calculating the estimated glomerular filtration rate by the Modification of Diet in Renal Disease equation. The Chi‐square test and ANOVA were used to estimate the difference of categorical and continuous variables, respectively. Polytomous logistic regression was employed to assess the odds ratio (OR) and 95% confidence intervals (CIs) of the sarcopenia status and sarcopenia‐associated risk factors in the predialysis CKD patients. All tests were two‐sided, and p < 0.05 was defined as statistical significance. Results Among the 3648 older adults (mean age: 71.9 ± 6.07 years), including 1701 males and 1947 females, 870 (23.9%), 94 (2.58%) and 48 (1.32%) had possible sarcopenia, sarcopenia and severe sarcopenia, respectively. After adjustment, the risk for possible sarcopenia, sarcopenia and severe sarcopenia significantly increased with ageing (OR = 1.11, 1.10 and 1.23; 95% CI = 1.10–1.13, 1.07–1.15 and 1.18–1.30, respectively) and male gender (OR = 2.26, 20.3 and 25.4; 95% CI = 1.87–2.73, 11.5–36.0 and 11.3–57.2, respectively). Compared with KDIGO G1, no significant association between KDIGO G3–5 and the statuses of sarcopenia was observed (OR = 0.97, 0.88 and 0.91; 95% CI = 0.75–1.26, 0.43–1.78 and 0.37–2.27, p = 0.821, 0.718, 0.838, for possible sarcopenia, sarcopenia and severe sarcopenia, respectively). Ageing and male gender indicated a significant risk for higher sarcopenia status in older patients with predialysis CKD (0.027‐fold/year and 0.284‐fold, respectively) (p < 0.0001). Conclusions This study illuminated the importance of the male sex and the ageing process on the risk of sarcopenia progression in patients with predialysis CKD. Early clinical screening and aggressive treatment for the prevention of higher sarcopenia status in advanced older male adults with predialysis CKD are recommended. |
| format | Article |
| id | doaj-art-b623fbbbfe8d4f27bd5d4e17f2f35421 |
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| issn | 2190-5991 2190-6009 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
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| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj-art-b623fbbbfe8d4f27bd5d4e17f2f354212025-08-20T02:34:20ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092024-12-011562684269210.1002/jcsm.13612Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on DialysisYi‐Fang Huang0Shih‐Ping Liu1Chih‐Hsin Muo2Chen‐Yi Lai3Chung‐Ta Chang4Department of General Dentistry Chang Gung Memorial Hospital Linkou TaiwanTranslational Medicine Research Center China Medical University Hospital Taichung TaiwanManagement Office for Health Data China Medical University Hospital Taichung TaiwanInternal Audit Department Far Eastern Memorial Hospital New Taipei TaiwanSchool of Dentistry, College of Oral Medicine Taipei Medical University Taipei TaiwanABSTRACT Background The risk of sarcopenia in older adults with chronic kidney disease (CKD) not yet on dialysis is controversial. The aims of this study were to investigate the association among sarcopenia, diabetes and predialysis CKD and evaluate the impact of gender and ageing on the risk of sarcopenia statuses in older patients with predialysis CKD. Methods The participants aged ≥60 years old were recruited from the community of New Taipei City, Taiwan. Handgrip strength, appendicular skeletal muscle mass and the 6‐m walk were measured. The diagnosis of sarcopenia was established based on the consensus of Asian Sarcopenia Working Group 2019. These older adults were categorised into G1, G2 and G3–5 according to the guidelines of Kidney Disease Improving Global Outcomes (KDIGO) after calculating the estimated glomerular filtration rate by the Modification of Diet in Renal Disease equation. The Chi‐square test and ANOVA were used to estimate the difference of categorical and continuous variables, respectively. Polytomous logistic regression was employed to assess the odds ratio (OR) and 95% confidence intervals (CIs) of the sarcopenia status and sarcopenia‐associated risk factors in the predialysis CKD patients. All tests were two‐sided, and p < 0.05 was defined as statistical significance. Results Among the 3648 older adults (mean age: 71.9 ± 6.07 years), including 1701 males and 1947 females, 870 (23.9%), 94 (2.58%) and 48 (1.32%) had possible sarcopenia, sarcopenia and severe sarcopenia, respectively. After adjustment, the risk for possible sarcopenia, sarcopenia and severe sarcopenia significantly increased with ageing (OR = 1.11, 1.10 and 1.23; 95% CI = 1.10–1.13, 1.07–1.15 and 1.18–1.30, respectively) and male gender (OR = 2.26, 20.3 and 25.4; 95% CI = 1.87–2.73, 11.5–36.0 and 11.3–57.2, respectively). Compared with KDIGO G1, no significant association between KDIGO G3–5 and the statuses of sarcopenia was observed (OR = 0.97, 0.88 and 0.91; 95% CI = 0.75–1.26, 0.43–1.78 and 0.37–2.27, p = 0.821, 0.718, 0.838, for possible sarcopenia, sarcopenia and severe sarcopenia, respectively). Ageing and male gender indicated a significant risk for higher sarcopenia status in older patients with predialysis CKD (0.027‐fold/year and 0.284‐fold, respectively) (p < 0.0001). Conclusions This study illuminated the importance of the male sex and the ageing process on the risk of sarcopenia progression in patients with predialysis CKD. Early clinical screening and aggressive treatment for the prevention of higher sarcopenia status in advanced older male adults with predialysis CKD are recommended.https://doi.org/10.1002/jcsm.13612ageingAWGS 2019chronic kidney diseasegenderolder adultsarcopenia |
| spellingShingle | Yi‐Fang Huang Shih‐Ping Liu Chih‐Hsin Muo Chen‐Yi Lai Chung‐Ta Chang Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis Journal of Cachexia, Sarcopenia and Muscle ageing AWGS 2019 chronic kidney disease gender older adult sarcopenia |
| title | Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis |
| title_full | Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis |
| title_fullStr | Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis |
| title_full_unstemmed | Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis |
| title_short | Male Sex and Ageing are Independent Risk Factors for Sarcopenia Stage in Patients With Chronic Kidney Disease Not Yet on Dialysis |
| title_sort | male sex and ageing are independent risk factors for sarcopenia stage in patients with chronic kidney disease not yet on dialysis |
| topic | ageing AWGS 2019 chronic kidney disease gender older adult sarcopenia |
| url | https://doi.org/10.1002/jcsm.13612 |
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