Human immune system: Exploring diversity across individuals and populations
The immune response is an intricate system that involves the complex connection of cellular and molecular components, each with distinct functional specialisations. It has a distinct capacity to adjust and mould the immune response in accordance with specific stimuli, influenced by both genetic and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025002166 |
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| author | Kim Han Hoang Nguyen Nghi Vinh Le Phuc Hoang Nguyen Hien Hau Thi Nguyen Duy Mai Hoang Chien Dinh Huynh |
| author_facet | Kim Han Hoang Nguyen Nghi Vinh Le Phuc Hoang Nguyen Hien Hau Thi Nguyen Duy Mai Hoang Chien Dinh Huynh |
| author_sort | Kim Han Hoang Nguyen |
| collection | DOAJ |
| description | The immune response is an intricate system that involves the complex connection of cellular and molecular components, each with distinct functional specialisations. It has a distinct capacity to adjust and mould the immune response in accordance with specific stimuli, influenced by both genetic and environmental factors. The presence of genetic diversity, particularly across different ethnic and racial groups, significantly contributes to the impact of incidence of diseases, disease susceptibility, autoimmune disorders, and cancer risks in specific regions and certain populations. Environmental factors, including geography and socioeconomic status, further modulate the variety of the immune system responses. These, in turn, affect the susceptibility to infectious diseases and development of autoimmune disorders. Despite the complexity of the relationship, there remains a gap in understanding the specificity of immune indices across races, immune reference ranges among populations, highlighting the need for deeper understanding of immune diversity for personalized approaches in diagnostics and therapeutics. This review systematically organizes these findings, with the goal of emphasizing the potential of targeted interventions to address health disparities and advance translational research, enabling a more comprehensive strategy. This approach promises significant advancements in identifying specific immunological conditions, focusing on personalized interventions, through both genetic and environmental factors. |
| format | Article |
| id | doaj-art-b603953223a3488c9c39f8382fb0be70 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-b603953223a3488c9c39f8382fb0be702025-02-02T05:28:20ZengElsevierHeliyon2405-84402025-01-01112e41836Human immune system: Exploring diversity across individuals and populationsKim Han Hoang Nguyen0Nghi Vinh Le1Phuc Hoang Nguyen2Hien Hau Thi Nguyen3Duy Mai Hoang4Chien Dinh Huynh5College of Health Sciences, VinUniversity, Hanoi, Viet NamCollege of Health Sciences, VinUniversity, Hanoi, Viet NamCollege of Health Sciences, VinUniversity, Hanoi, Viet NamCollege of Health Sciences, VinUniversity, Hanoi, Viet Nam; Institute of Research and Development, Duy Tan University, Da Nang, Viet Nam; School of Medicine and Pharmacy, Duy Tan University, Da Nang, Viet NamCollege of Health Sciences, VinUniversity, Hanoi, Viet NamCollege of Health Sciences, VinUniversity, Hanoi, Viet Nam; Corresponding author.The immune response is an intricate system that involves the complex connection of cellular and molecular components, each with distinct functional specialisations. It has a distinct capacity to adjust and mould the immune response in accordance with specific stimuli, influenced by both genetic and environmental factors. The presence of genetic diversity, particularly across different ethnic and racial groups, significantly contributes to the impact of incidence of diseases, disease susceptibility, autoimmune disorders, and cancer risks in specific regions and certain populations. Environmental factors, including geography and socioeconomic status, further modulate the variety of the immune system responses. These, in turn, affect the susceptibility to infectious diseases and development of autoimmune disorders. Despite the complexity of the relationship, there remains a gap in understanding the specificity of immune indices across races, immune reference ranges among populations, highlighting the need for deeper understanding of immune diversity for personalized approaches in diagnostics and therapeutics. This review systematically organizes these findings, with the goal of emphasizing the potential of targeted interventions to address health disparities and advance translational research, enabling a more comprehensive strategy. This approach promises significant advancements in identifying specific immunological conditions, focusing on personalized interventions, through both genetic and environmental factors.http://www.sciencedirect.com/science/article/pii/S2405844025002166Immune systemDiversityPopulationAutoimmunityCancerInfection |
| spellingShingle | Kim Han Hoang Nguyen Nghi Vinh Le Phuc Hoang Nguyen Hien Hau Thi Nguyen Duy Mai Hoang Chien Dinh Huynh Human immune system: Exploring diversity across individuals and populations Heliyon Immune system Diversity Population Autoimmunity Cancer Infection |
| title | Human immune system: Exploring diversity across individuals and populations |
| title_full | Human immune system: Exploring diversity across individuals and populations |
| title_fullStr | Human immune system: Exploring diversity across individuals and populations |
| title_full_unstemmed | Human immune system: Exploring diversity across individuals and populations |
| title_short | Human immune system: Exploring diversity across individuals and populations |
| title_sort | human immune system exploring diversity across individuals and populations |
| topic | Immune system Diversity Population Autoimmunity Cancer Infection |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025002166 |
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