Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study
Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained t...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225000075 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573240568971264 |
|---|---|
| author | Jun Kanzawa Ryo Kurokawa Tsunehiko Takamura Nobuhiro Nohara Kouhei Kamiya Yoshiya Moriguchi Yasuhiro Sato Yumi Hamamoto Tomotaka Shoji Tomohiko Muratsubaki Motoaki Sugiura Shin Fukudo Yoshiyuki Hirano Yusuke Sudo Rio Kamashita Sayo Hamatani Noriko Numata Koji Matsumoto Eiji Shimizu Naoki Kodama Shingo Kakeda Masatoshi Takahashi Satoru Ide Kazumasa Okada Shu Takakura Motoharu Gondo Kazufumi Yoshihara Masanori Isobe Keima Tose Tomomi Noda Ryo Mishima Michiko Kawabata Shun’ichi Noma Toshiya Murai Kazuhiro Yoshiuchi Atsushi Sekiguchi Osamu Abe |
| author_facet | Jun Kanzawa Ryo Kurokawa Tsunehiko Takamura Nobuhiro Nohara Kouhei Kamiya Yoshiya Moriguchi Yasuhiro Sato Yumi Hamamoto Tomotaka Shoji Tomohiko Muratsubaki Motoaki Sugiura Shin Fukudo Yoshiyuki Hirano Yusuke Sudo Rio Kamashita Sayo Hamatani Noriko Numata Koji Matsumoto Eiji Shimizu Naoki Kodama Shingo Kakeda Masatoshi Takahashi Satoru Ide Kazumasa Okada Shu Takakura Motoharu Gondo Kazufumi Yoshihara Masanori Isobe Keima Tose Tomomi Noda Ryo Mishima Michiko Kawabata Shun’ichi Noma Toshiya Murai Kazuhiro Yoshiuchi Atsushi Sekiguchi Osamu Abe |
| author_sort | Jun Kanzawa |
| collection | DOAJ |
| description | Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions. |
| format | Article |
| id | doaj-art-b602fdfedb5846c2825afb36e00026f2 |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-b602fdfedb5846c2825afb36e00026f22025-02-02T05:27:09ZengElsevierNeuroImage: Clinical2213-15822025-01-0145103737Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity studyJun Kanzawa0Ryo Kurokawa1Tsunehiko Takamura2Nobuhiro Nohara3Kouhei Kamiya4Yoshiya Moriguchi5Yasuhiro Sato6Yumi Hamamoto7Tomotaka Shoji8Tomohiko Muratsubaki9Motoaki Sugiura10Shin Fukudo11Yoshiyuki Hirano12Yusuke Sudo13Rio Kamashita14Sayo Hamatani15Noriko Numata16Koji Matsumoto17Eiji Shimizu18Naoki Kodama19Shingo Kakeda20Masatoshi Takahashi21Satoru Ide22Kazumasa Okada23Shu Takakura24Motoharu Gondo25Kazufumi Yoshihara26Masanori Isobe27Keima Tose28Tomomi Noda29Ryo Mishima30Michiko Kawabata31Shun’ichi Noma32Toshiya Murai33Kazuhiro Yoshiuchi34Atsushi Sekiguchi35Osamu Abe36Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Corresponding author.Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Psychosomatic Medicine, The University of Tokyo Hospital, Tokyo, JapanDepartment of Radiology, Toho University Omori Faculty of Medicine, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan; Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, JapanCreative Interdisciplinary Research Division, The Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan; Research Institute of Electrical Communication, Tohoku University, Sendai, JapanNagamachi Hospital, Sendai, JapanDepartment of Psychosomatic Medicine, Tohoku University Hospital, Sendai, JapanDepartment of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; International Research Institute of Disaster Science, Tohoku University, Sendai, JapanDepartment of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Research Center for Accelerator and Radioisotope Science, Tohoku University, Sendai, JapanResearch Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Applied MRI Research, Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, JapanResearch Center for Child Mental Development Chiba University, Chiba, Japan; Department of Cognitive Behavioral Physiology, Chiba University, Chiba, Japan; Department of Psychiatry, Chiba University Hospital, Chiba, JapanResearch Center for Child Mental Development Chiba University, Chiba, Japan; Department of Rehabilitation, Faculty of Health Sciences, Hiroshima Cosmopolitan University, Hiroshima, JapanResearch Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Research Center for Child Mental Development Fukui University, Eiheizi, JapanResearch Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Department of Cognitive Behavioral Physiology, Chiba University, Chiba, JapanDepartment of Radiology, Chiba University Hospital, Chiba, JapanResearch Center for Child Mental Development Chiba University, Chiba, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan; Department of Cognitive Behavioral Physiology, Chiba University, Chiba, JapanDivision of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Radiology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, JapanDivision of Psychosomatic Medicine, Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, JapanDepartment of Radiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, JapanDepartment of Neurology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, JapanDepartment of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, JapanDepartment of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, JapanDepartment of Psychosomatic Medicine, Kyushu University Hospital, Fukuoka, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Nomakokoro Clinic, Kyoto, JapanDepartment of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, JapanDepartment of Stress Sciences and Psychosomatic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan; Center for Eating Disorder Research and Information, National Center of Neurology and Psychiatry, Tokyo, JapanDepartment of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanAnorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.http://www.sciencedirect.com/science/article/pii/S2213158225000075Anorexia Nervosa (AN)Diffusion MRIStructural ConnectivityGraph TheorySingle-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD) |
| spellingShingle | Jun Kanzawa Ryo Kurokawa Tsunehiko Takamura Nobuhiro Nohara Kouhei Kamiya Yoshiya Moriguchi Yasuhiro Sato Yumi Hamamoto Tomotaka Shoji Tomohiko Muratsubaki Motoaki Sugiura Shin Fukudo Yoshiyuki Hirano Yusuke Sudo Rio Kamashita Sayo Hamatani Noriko Numata Koji Matsumoto Eiji Shimizu Naoki Kodama Shingo Kakeda Masatoshi Takahashi Satoru Ide Kazumasa Okada Shu Takakura Motoharu Gondo Kazufumi Yoshihara Masanori Isobe Keima Tose Tomomi Noda Ryo Mishima Michiko Kawabata Shun’ichi Noma Toshiya Murai Kazuhiro Yoshiuchi Atsushi Sekiguchi Osamu Abe Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study NeuroImage: Clinical Anorexia Nervosa (AN) Diffusion MRI Structural Connectivity Graph Theory Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD) |
| title | Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study |
| title_full | Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study |
| title_fullStr | Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study |
| title_full_unstemmed | Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study |
| title_short | Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study |
| title_sort | brain network alterations in anorexia nervosa a multi center structural connectivity study |
| topic | Anorexia Nervosa (AN) Diffusion MRI Structural Connectivity Graph Theory Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD) |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225000075 |
| work_keys_str_mv | AT junkanzawa brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT ryokurokawa brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT tsunehikotakamura brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT nobuhironohara brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT kouheikamiya brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT yoshiyamoriguchi brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT yasuhirosato brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT yumihamamoto brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT tomotakashoji brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT tomohikomuratsubaki brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT motoakisugiura brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT shinfukudo brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT yoshiyukihirano brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT yusukesudo brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT riokamashita brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT sayohamatani brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT norikonumata brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT kojimatsumoto brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT eijishimizu brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT naokikodama brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT shingokakeda brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT masatoshitakahashi brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT satoruide brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT kazumasaokada brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT shutakakura brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT motoharugondo brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT kazufumiyoshihara brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT masanoriisobe brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT keimatose brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT tomominoda brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT ryomishima brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT michikokawabata brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT shunichinoma brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT toshiyamurai brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT kazuhiroyoshiuchi brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT atsushisekiguchi brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy AT osamuabe brainnetworkalterationsinanorexianervosaamulticenterstructuralconnectivitystudy |