Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study

Brain network alterations in anorexia Nervosa: A Multi-Center structural connectivity study

Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained t...

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Main Authors: Jun Kanzawa, Ryo Kurokawa, Tsunehiko Takamura, Nobuhiro Nohara, Kouhei Kamiya, Yoshiya Moriguchi, Yasuhiro Sato, Yumi Hamamoto, Tomotaka Shoji, Tomohiko Muratsubaki, Motoaki Sugiura, Shin Fukudo, Yoshiyuki Hirano, Yusuke Sudo, Rio Kamashita, Sayo Hamatani, Noriko Numata, Koji Matsumoto, Eiji Shimizu, Naoki Kodama, Shingo Kakeda, Masatoshi Takahashi, Satoru Ide, Kazumasa Okada, Shu Takakura, Motoharu Gondo, Kazufumi Yoshihara, Masanori Isobe, Keima Tose, Tomomi Noda, Ryo Mishima, Michiko Kawabata, Shun’ichi Noma, Toshiya Murai, Kazuhiro Yoshiuchi, Atsushi Sekiguchi, Osamu Abe
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:NeuroImage: Clinical
Subjects:
Anorexia Nervosa (AN)
Diffusion MRI
Structural Connectivity
Graph Theory
Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158225000075
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Summary:Anorexia nervosa (AN) is a severe eating disorder characterized by intense fear of weight gain, distorted body image, and extreme food restriction. This research employed advanced diffusion MRI techniques including single-shell 3-tissue constrained spherical deconvolution, anatomically constrained tractography, and spherical deconvolution informed filtering of tractograms to analyze brain network alterations in AN. Diffusion MRI data from 81 AN patients and 98 healthy controls were obtained. The structural brain connectome was constructed based on nodes set in 84 brain regions, and graph theory analysis was conducted. Results showed that AN patients exhibited significantly higher clustering coefficient and local efficiency in several brain regions, including the left fusiform gyrus, bilateral orbitofrontal cortex, right entorhinal cortex, right lateral occipital gyrus, right superior temporal gyrus, and right insula. A trend towards higher global efficiency and small-worldness was also observed in AN patients, although not statistically significant. These findings suggest increased local connectivity and efficiency within regions associated with behavioral rigidity, emotional regulation, and disturbed body image among AN patients. This study contributes to the understanding of the neurological basis of AN by highlighting structural connectivity alterations in specific brain regions.
ISSN:2213-1582

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