IL-18 biology in severe asthma
The role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has garnered significant attention in recent years. This review aims to provide an overview of the current understanding of IL-18 biology, th...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-11-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1486780/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832593433001197568 |
|---|---|
| author | Sarita Thawanaphong Sarita Thawanaphong Sarita Thawanaphong Aswathi Nair Aswathi Nair Emily Volfson Emily Volfson Parameswaran Nair Parameswaran Nair Manali Mukherjee Manali Mukherjee |
| author_facet | Sarita Thawanaphong Sarita Thawanaphong Sarita Thawanaphong Aswathi Nair Aswathi Nair Emily Volfson Emily Volfson Parameswaran Nair Parameswaran Nair Manali Mukherjee Manali Mukherjee |
| author_sort | Sarita Thawanaphong |
| collection | DOAJ |
| description | The role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has garnered significant attention in recent years. This review aims to provide an overview of the current understanding of IL-18 biology, the associated signaling pathways, and the involvement of inflammasome complexes in airway diseases. We explore the multifaceted role of IL-18 in asthma pathophysiology, including its interactions with other cytokines and contributions to both T2 and non-T2 inflammation. Importantly, emerging evidence highlights IL-18 as a critical player in severe asthma, contributing to chronic airway inflammation, airway hyperresponsiveness (AHR), and mucus impaction. Furthermore, we discuss the emerging evidence of IL-18’s involvement in autoimmunity and highlight potential therapeutic targets within the IL-18 and inflammasome pathways in severe asthma patients with evidence of infections and airway autoimmune responses. By synthesizing recent advancements and ongoing research, this review underscores the importance of IL-18 as a potential novel therapeutic target in the treatment of severe asthma and other related conditions. |
| format | Article |
| id | doaj-art-b60127850ecf43cd903e3a574276fc2d |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-b60127850ecf43cd903e3a574276fc2d2025-01-20T15:48:50ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-11-011110.3389/fmed.2024.14867801486780IL-18 biology in severe asthmaSarita Thawanaphong0Sarita Thawanaphong1Sarita Thawanaphong2Aswathi Nair3Aswathi Nair4Emily Volfson5Emily Volfson6Parameswaran Nair7Parameswaran Nair8Manali Mukherjee9Manali Mukherjee10Department of Medicine, McMAster University, Hamilton, ON, CanadaResearch Institute of St. Joe’s Hamilton, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, ThailandDepartment of Medicine, McMAster University, Hamilton, ON, CanadaResearch Institute of St. Joe’s Hamilton, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaDepartment of Medicine, McMAster University, Hamilton, ON, CanadaResearch Institute of St. Joe’s Hamilton, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaDepartment of Medicine, McMAster University, Hamilton, ON, CanadaResearch Institute of St. Joe’s Hamilton, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaDepartment of Medicine, McMAster University, Hamilton, ON, CanadaResearch Institute of St. Joe’s Hamilton, St. Joseph’s Healthcare Hamilton, Hamilton, ON, CanadaThe role of interleukin-18 (IL-18) and inflammasomes in chronic inflammatory airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), has garnered significant attention in recent years. This review aims to provide an overview of the current understanding of IL-18 biology, the associated signaling pathways, and the involvement of inflammasome complexes in airway diseases. We explore the multifaceted role of IL-18 in asthma pathophysiology, including its interactions with other cytokines and contributions to both T2 and non-T2 inflammation. Importantly, emerging evidence highlights IL-18 as a critical player in severe asthma, contributing to chronic airway inflammation, airway hyperresponsiveness (AHR), and mucus impaction. Furthermore, we discuss the emerging evidence of IL-18’s involvement in autoimmunity and highlight potential therapeutic targets within the IL-18 and inflammasome pathways in severe asthma patients with evidence of infections and airway autoimmune responses. By synthesizing recent advancements and ongoing research, this review underscores the importance of IL-18 as a potential novel therapeutic target in the treatment of severe asthma and other related conditions.https://www.frontiersin.org/articles/10.3389/fmed.2024.1486780/fullIL-18autoimmunityasthmainflammasomeeosinophilia |
| spellingShingle | Sarita Thawanaphong Sarita Thawanaphong Sarita Thawanaphong Aswathi Nair Aswathi Nair Emily Volfson Emily Volfson Parameswaran Nair Parameswaran Nair Manali Mukherjee Manali Mukherjee IL-18 biology in severe asthma Frontiers in Medicine IL-18 autoimmunity asthma inflammasome eosinophilia |
| title | IL-18 biology in severe asthma |
| title_full | IL-18 biology in severe asthma |
| title_fullStr | IL-18 biology in severe asthma |
| title_full_unstemmed | IL-18 biology in severe asthma |
| title_short | IL-18 biology in severe asthma |
| title_sort | il 18 biology in severe asthma |
| topic | IL-18 autoimmunity asthma inflammasome eosinophilia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1486780/full |
| work_keys_str_mv | AT saritathawanaphong il18biologyinsevereasthma AT saritathawanaphong il18biologyinsevereasthma AT saritathawanaphong il18biologyinsevereasthma AT aswathinair il18biologyinsevereasthma AT aswathinair il18biologyinsevereasthma AT emilyvolfson il18biologyinsevereasthma AT emilyvolfson il18biologyinsevereasthma AT parameswarannair il18biologyinsevereasthma AT parameswarannair il18biologyinsevereasthma AT manalimukherjee il18biologyinsevereasthma AT manalimukherjee il18biologyinsevereasthma |