A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing
A 27-year-old Caucasian female with a history of depression was admitted to our local hospital with vague events that occurred a day before. This included an episode of dysarthria, and unsteadiness, followed by feeling generally unwell. Two weeks prior to presentation she was commenced on phenelzine...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/931963 |
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| author | A. Malik N. Junglee |
| author_facet | A. Malik N. Junglee |
| author_sort | A. Malik |
| collection | DOAJ |
| description | A 27-year-old Caucasian female with a history of depression was admitted to our local hospital with vague events that occurred a day before. This included an episode of dysarthria, and unsteadiness, followed by feeling generally unwell. Two weeks prior to presentation she was commenced on phenelzine. During clinical assessment she suddenly deteriorated with a dramatic fall in her conscious level. Moreover, she became hyperthermic, tachycardic, and diaphoretic, and developed increased tone in all muscles and ocular clonus. Rectal diazepam was administered but failed to control the symptoms. Consequently, she was transferred to the intensive care unit for intubation and muscle relaxants were commenced. She responded well and recovered next day without complications. Her symptoms and signs were consistent with the serotonin syndrome with phenelzine being the likely cause. To the best of our knowledge, this is the first reported case to associate the condition with phenelzine alone at therapeutic dose. |
| format | Article |
| id | doaj-art-b5fb0161eaec41f4933c32b70703d572 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b5fb0161eaec41f4933c32b70703d5722025-02-03T01:30:51ZengWileyCase Reports in Medicine1687-96271687-96352015-01-01201510.1155/2015/931963931963A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic DosingA. Malik0N. Junglee1Morriston Hospital, Swansea, Wales SA6 6NL, UKUniversity Hospital of Wales, Cardiff, Wales CF14 4XW, UKA 27-year-old Caucasian female with a history of depression was admitted to our local hospital with vague events that occurred a day before. This included an episode of dysarthria, and unsteadiness, followed by feeling generally unwell. Two weeks prior to presentation she was commenced on phenelzine. During clinical assessment she suddenly deteriorated with a dramatic fall in her conscious level. Moreover, she became hyperthermic, tachycardic, and diaphoretic, and developed increased tone in all muscles and ocular clonus. Rectal diazepam was administered but failed to control the symptoms. Consequently, she was transferred to the intensive care unit for intubation and muscle relaxants were commenced. She responded well and recovered next day without complications. Her symptoms and signs were consistent with the serotonin syndrome with phenelzine being the likely cause. To the best of our knowledge, this is the first reported case to associate the condition with phenelzine alone at therapeutic dose.http://dx.doi.org/10.1155/2015/931963 |
| spellingShingle | A. Malik N. Junglee A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing Case Reports in Medicine |
| title | A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing |
| title_full | A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing |
| title_fullStr | A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing |
| title_full_unstemmed | A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing |
| title_short | A Case of the Serotonin Syndrome Secondary to Phenelzine Monotherapy at Therapeutic Dosing |
| title_sort | case of the serotonin syndrome secondary to phenelzine monotherapy at therapeutic dosing |
| url | http://dx.doi.org/10.1155/2015/931963 |
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