Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population
We studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities. The health status of population was examined from the areas of Kanpur (India) having the elevated hexavalent chromium levels in groundwater. Blood samples were collected for DNA isolation to conduct po...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.1155/2012/968641 |
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| author | Priti Sharma Vipin Bihari Sudhir K. Agarwal Sudhir K. Goel |
| author_facet | Priti Sharma Vipin Bihari Sudhir K. Agarwal Sudhir K. Goel |
| author_sort | Priti Sharma |
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| description | We studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities. The health status of population was examined from the areas of Kanpur (India) having the elevated hexavalent chromium levels in groundwater. Blood samples were collected for DNA isolation to conduct polymorphic determination of genes, namely: NQO1 (C609T), hOGG1 (C1245G), GSTT1, and GSTM1 (deletion). Symptomatic exposed subjects (n=38) were compared with asymptomatic exposed subjects (n=108) along with asymptomatic controls (n=148) from a non contaminated reference community. Exposed symptomatic group consisted of 36.8% subjects who were GSTM1 null genotyped as compared to asymptomatic where only 19.4% subjects were null. The exposed subjects with GSTM1 null genotype were more susceptible to dermal adversities in comparison with wild genotyped subjects (OR = 2.42; 95% CI = 1.071–5.451). Age, smoking, gender or duration of residence were not found to have any confounding effect towards this association. Association with other genes was not statistically significant, nonetheless, possible contribution by these genes cannot be ruled out. In conclusion, variation in the polymorphic status of GSTM1 gene may influence dermal outcomes among residents from Cr(VI) contaminated areas. Further studies are therefore, needed to examine these observations among different population groups. |
| format | Article |
| id | doaj-art-b5eeb5364ae940efbea4eb8ba21aaa58 |
| institution | Kabale University |
| issn | 2090-0201 2090-021X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-b5eeb5364ae940efbea4eb8ba21aaa582025-02-03T01:13:11ZengWileyJournal of Nucleic Acids2090-02012090-021X2012-01-01201210.1155/2012/968641968641Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed PopulationPriti Sharma0Vipin Bihari1Sudhir K. Agarwal2Sudhir K. Goel3Petroleum Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, IndiaEpidemiology Division, CSIR-IITR, Lucknow 226001, IndiaDepartment of Biochemistry, Lucknow University, Lucknow 226007, IndiaPetroleum Toxicology Division, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226001, IndiaWe studied the effect of genetic susceptibility on hexavalent chromium induced dermal adversities. The health status of population was examined from the areas of Kanpur (India) having the elevated hexavalent chromium levels in groundwater. Blood samples were collected for DNA isolation to conduct polymorphic determination of genes, namely: NQO1 (C609T), hOGG1 (C1245G), GSTT1, and GSTM1 (deletion). Symptomatic exposed subjects (n=38) were compared with asymptomatic exposed subjects (n=108) along with asymptomatic controls (n=148) from a non contaminated reference community. Exposed symptomatic group consisted of 36.8% subjects who were GSTM1 null genotyped as compared to asymptomatic where only 19.4% subjects were null. The exposed subjects with GSTM1 null genotype were more susceptible to dermal adversities in comparison with wild genotyped subjects (OR = 2.42; 95% CI = 1.071–5.451). Age, smoking, gender or duration of residence were not found to have any confounding effect towards this association. Association with other genes was not statistically significant, nonetheless, possible contribution by these genes cannot be ruled out. In conclusion, variation in the polymorphic status of GSTM1 gene may influence dermal outcomes among residents from Cr(VI) contaminated areas. Further studies are therefore, needed to examine these observations among different population groups.http://dx.doi.org/10.1155/2012/968641 |
| spellingShingle | Priti Sharma Vipin Bihari Sudhir K. Agarwal Sudhir K. Goel Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population Journal of Nucleic Acids |
| title | Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population |
| title_full | Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population |
| title_fullStr | Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population |
| title_full_unstemmed | Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population |
| title_short | Genetic Predisposition for Dermal Problems in Hexavalent Chromium Exposed Population |
| title_sort | genetic predisposition for dermal problems in hexavalent chromium exposed population |
| url | http://dx.doi.org/10.1155/2012/968641 |
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