Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018
Abstract the high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio and hyperuricemia among the population of the United States, the ratio still has predictive value for cardiovascular disease in middle age. Methods 4,780 adult participators from the Natio...
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2025-03-01
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| author | Wei Jinfeng Guo Jinhao Yin Xianglin Qiu Hongbin Zheng Jiarui |
| author_facet | Wei Jinfeng Guo Jinhao Yin Xianglin Qiu Hongbin Zheng Jiarui |
| author_sort | Wei Jinfeng |
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| description | Abstract the high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio and hyperuricemia among the population of the United States, the ratio still has predictive value for cardiovascular disease in middle age. Methods 4,780 adult participators from the National Health and Nutrition Examination Survey (NHANES) were involved in this research. Through the NHANES laboratory testing, all biochemical indications were discovered. In order to observe the differences in indications, propensity score methods were used to match age and sex confounders.The relationship between hs-CRP/HDL-C ratio and hyperuricemia was explored using propensity matching and weighted multivariate logistic regression analysis, with the potential nonlinear relationship between hs-CRP/HDL-C ratio and hyperuricemia was investigated using a restricted cubic spline test. Results Sex, age, hypercholesterolaemia, diabetes, fasting glucose, cholesterol, high and low density lipoprotein, did not differ statistically significantly (P > 0.05); however, uric acid, triglycerides, high-density lipoprotein, CRP/HDL ratio, C-reactive protein, ethnicity, and hypertriglyceridemia differed (P < 0.05). In a weighted multifactor model, the relative odds ratio for hyperuricemia increased by 0.383 times at the second quintile (OR = 1.383, 95%CI(1.382–1.385), P < 0.001), 2.001 times at the third quintile (OR = 3.001, 95%CI (2.998–3.005), P < 0.001), and 2.533 times at the fourth quintile (OR = 3.533, 95%CI (3.529–3.538), P < 0.001). In the univariate and multivariate models, the restricted cubic spline test demonstrated a nonlinear correlation between the CRP/HDL ratio and hyperuricaemia, with a growing “log-function” shaped trend (P for overall < 0.001). Conclusion The hs-CRP/HDL-C ratio is significantly positively correlated with hyperuricemia among American adults. Maintaining the ideal hs-CRP/HDL-C ratio may contribute to reducing the burden of hyperuricemia. |
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| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-b5ec5de749f74b3c9ee5ba4b48c91d9c2025-08-20T02:56:15ZengNature PortfolioScientific Reports2045-23222025-03-011511710.1038/s41598-024-83126-8Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018Wei Jinfeng0Guo Jinhao1Yin Xianglin2Qiu Hongbin3Zheng Jiarui4School of Public Health, Jiamusi UniversitySchool of Public Health, Jiamusi UniversitySchool of Public Health, Jiamusi UniversitySchool of Public Health, Jiamusi UniversityFirst Affiliated Hospital of Jiamusi UniversityAbstract the high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio and hyperuricemia among the population of the United States, the ratio still has predictive value for cardiovascular disease in middle age. Methods 4,780 adult participators from the National Health and Nutrition Examination Survey (NHANES) were involved in this research. Through the NHANES laboratory testing, all biochemical indications were discovered. In order to observe the differences in indications, propensity score methods were used to match age and sex confounders.The relationship between hs-CRP/HDL-C ratio and hyperuricemia was explored using propensity matching and weighted multivariate logistic regression analysis, with the potential nonlinear relationship between hs-CRP/HDL-C ratio and hyperuricemia was investigated using a restricted cubic spline test. Results Sex, age, hypercholesterolaemia, diabetes, fasting glucose, cholesterol, high and low density lipoprotein, did not differ statistically significantly (P > 0.05); however, uric acid, triglycerides, high-density lipoprotein, CRP/HDL ratio, C-reactive protein, ethnicity, and hypertriglyceridemia differed (P < 0.05). In a weighted multifactor model, the relative odds ratio for hyperuricemia increased by 0.383 times at the second quintile (OR = 1.383, 95%CI(1.382–1.385), P < 0.001), 2.001 times at the third quintile (OR = 3.001, 95%CI (2.998–3.005), P < 0.001), and 2.533 times at the fourth quintile (OR = 3.533, 95%CI (3.529–3.538), P < 0.001). In the univariate and multivariate models, the restricted cubic spline test demonstrated a nonlinear correlation between the CRP/HDL ratio and hyperuricaemia, with a growing “log-function” shaped trend (P for overall < 0.001). Conclusion The hs-CRP/HDL-C ratio is significantly positively correlated with hyperuricemia among American adults. Maintaining the ideal hs-CRP/HDL-C ratio may contribute to reducing the burden of hyperuricemia.https://doi.org/10.1038/s41598-024-83126-8HyperuricemiaHs-CRP/HDL-C ratioHs-CRPHDL-CNHANESPropensity score matching |
| spellingShingle | Wei Jinfeng Guo Jinhao Yin Xianglin Qiu Hongbin Zheng Jiarui Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018 Scientific Reports Hyperuricemia Hs-CRP/HDL-C ratio Hs-CRP HDL-C NHANES Propensity score matching |
| title | Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018 |
| title_full | Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018 |
| title_fullStr | Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018 |
| title_full_unstemmed | Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018 |
| title_short | Correlation of the lipid complex marker hs-CRP/HDL-C ratio with hyperuricaemia: a cross-sectional retrospective study from NHANES 2015–2018 |
| title_sort | correlation of the lipid complex marker hs crp hdl c ratio with hyperuricaemia a cross sectional retrospective study from nhanes 2015 2018 |
| topic | Hyperuricemia Hs-CRP/HDL-C ratio Hs-CRP HDL-C NHANES Propensity score matching |
| url | https://doi.org/10.1038/s41598-024-83126-8 |
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