TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Since the precursor frequency of naive T cells is extremely low, investigating the early steps of antigen-specific T cell activation is challenging. To overcome this detection problem, adoptive transfer of a cohort of T cells purified from T cell receptor (TCR) transgenic donors has been extensively...

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Bibliographic Details
Main Authors: Nincy Debeuf, Sahine Lameire, Manon Vanheerswynghels, Julie Deckers, Caroline De Wolf, Wendy Toussaint, Rein Verbeke, Kevin Verstaen, Hamida Hammad, Stijn Vanhee, Bart N Lambrecht
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
SARS-CoV-2
TCR transgenic mouse
single-cell RNA analysis
VDJseq
Online Access:https://elifesciences.org/articles/98344
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