Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia
Purpose. Sarcopenia is an advancing and widespread skeletal muscle condition characterized by the depletion of skeletal muscle mass. The (pro)renin receptor ((P)RR) is a multifaceted protein with both pathophysiological and physiological functions. (P)RR is cleaved to generate soluble (P)RR, whose b...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2024/1899742 |
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| author | Satoshi Morimoto Haruki Sasaki Chikahito Suda Atsuhiro Ichihara Nobuyuki Ura |
| author_facet | Satoshi Morimoto Haruki Sasaki Chikahito Suda Atsuhiro Ichihara Nobuyuki Ura |
| author_sort | Satoshi Morimoto |
| collection | DOAJ |
| description | Purpose. Sarcopenia is an advancing and widespread skeletal muscle condition characterized by the depletion of skeletal muscle mass. The (pro)renin receptor ((P)RR) is a multifaceted protein with both pathophysiological and physiological functions. (P)RR is cleaved to generate soluble (P)RR, whose blood concentration may reflect the expression level of tissue (P)RR. We have discovered that the expression of (P)RR was elevated in the atrophied skeletal muscles of aged mice and humans. Methods. In this study, we examined the correlation between muscle atrophy and serum soluble (P)RR levels in bedridden patients with sarcopenia. Results. In total, 45 subjects were enrolled. Their ages were 81 (59–89) y.o., and serum soluble (P)RR levels were 30.5 ± 7.3 ng/ml. Lean body mass ratio (lean body mass/body weight), an index of muscle mass, was independently significantly and negatively correlated with serum soluble (P)RR concentrations in all patients. In addition, the lean body mass ratio was independently significantly and negatively correlated with serum soluble (P)RR concentrations in older patients (≥82 y.o.) but not in younger patients (<82 y.o.). Conclusion. These data suggested that patients with sarcopenia, especially in elderly patients, may be associated with increased (P)RR expression. The serum soluble (P)RR level could be a biomarker of sarcopenia although this issue should be investigated by future studies. |
| format | Article |
| id | doaj-art-b5e0fe892907402da02969c998a88b9c |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b5e0fe892907402da02969c998a88b9c2025-02-03T10:20:06ZengWileyInternational Journal of Endocrinology1687-83452024-01-01202410.1155/2024/1899742Increased Serum Soluble (Pro)renin Receptor Levels in Patients with SarcopeniaSatoshi Morimoto0Haruki Sasaki1Chikahito Suda2Atsuhiro Ichihara3Nobuyuki Ura4Department of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicineDepartment of Internal MedicinePurpose. Sarcopenia is an advancing and widespread skeletal muscle condition characterized by the depletion of skeletal muscle mass. The (pro)renin receptor ((P)RR) is a multifaceted protein with both pathophysiological and physiological functions. (P)RR is cleaved to generate soluble (P)RR, whose blood concentration may reflect the expression level of tissue (P)RR. We have discovered that the expression of (P)RR was elevated in the atrophied skeletal muscles of aged mice and humans. Methods. In this study, we examined the correlation between muscle atrophy and serum soluble (P)RR levels in bedridden patients with sarcopenia. Results. In total, 45 subjects were enrolled. Their ages were 81 (59–89) y.o., and serum soluble (P)RR levels were 30.5 ± 7.3 ng/ml. Lean body mass ratio (lean body mass/body weight), an index of muscle mass, was independently significantly and negatively correlated with serum soluble (P)RR concentrations in all patients. In addition, the lean body mass ratio was independently significantly and negatively correlated with serum soluble (P)RR concentrations in older patients (≥82 y.o.) but not in younger patients (<82 y.o.). Conclusion. These data suggested that patients with sarcopenia, especially in elderly patients, may be associated with increased (P)RR expression. The serum soluble (P)RR level could be a biomarker of sarcopenia although this issue should be investigated by future studies.http://dx.doi.org/10.1155/2024/1899742 |
| spellingShingle | Satoshi Morimoto Haruki Sasaki Chikahito Suda Atsuhiro Ichihara Nobuyuki Ura Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia International Journal of Endocrinology |
| title | Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia |
| title_full | Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia |
| title_fullStr | Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia |
| title_full_unstemmed | Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia |
| title_short | Increased Serum Soluble (Pro)renin Receptor Levels in Patients with Sarcopenia |
| title_sort | increased serum soluble pro renin receptor levels in patients with sarcopenia |
| url | http://dx.doi.org/10.1155/2024/1899742 |
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