Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement
Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/970793 |
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| author | Emaddin Kidher Vanash M. Patel Petros Nihoyannopoulos Jon R. Anderson Andrew Chukwuemeka Darrel P. Francis Hutan Ashrafian Thanos Athanasiou |
| author_facet | Emaddin Kidher Vanash M. Patel Petros Nihoyannopoulos Jon R. Anderson Andrew Chukwuemeka Darrel P. Francis Hutan Ashrafian Thanos Athanasiou |
| author_sort | Emaddin Kidher |
| collection | DOAJ |
| description | Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods. Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results. Fifty-six patients (71 ± 8.4
years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group (n=21) than in PWV-norm group (n=35; median 1.8±1.2 versus 1.2 ± 0.7, resp., P=0.003). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion. Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab. |
| format | Article |
| id | doaj-art-b5d623e6f2094258b7efb03d5021d318 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-b5d623e6f2094258b7efb03d5021d3182025-02-03T01:04:58ZengWileyNeurology Research International2090-18522090-18602014-01-01201410.1155/2014/970793970793Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve ReplacementEmaddin Kidher0Vanash M. Patel1Petros Nihoyannopoulos2Jon R. Anderson3Andrew Chukwuemeka4Darrel P. Francis5Hutan Ashrafian6Thanos Athanasiou7Department of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Campus, London W2 1NY, UKDepartment of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Campus, London W2 1NY, UKDepartments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UKDepartments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UKDepartments of Cardiac Surgery and Cardiology, Imperial College Healthcare NHS Trust, London W12 0HS, UKInternational Centre for Circulatory Health, Imperial College Healthcare NHS Trust, London W2 1LA, UKDepartment of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Campus, London W2 1NY, UKDepartment of Surgery and Cancer, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Campus, London W2 1NY, UKBackground. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods. Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results. Fifty-six patients (71 ± 8.4 years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group (n=21) than in PWV-norm group (n=35; median 1.8±1.2 versus 1.2 ± 0.7, resp., P=0.003). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion. Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.http://dx.doi.org/10.1155/2014/970793 |
| spellingShingle | Emaddin Kidher Vanash M. Patel Petros Nihoyannopoulos Jon R. Anderson Andrew Chukwuemeka Darrel P. Francis Hutan Ashrafian Thanos Athanasiou Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement Neurology Research International |
| title | Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement |
| title_full | Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement |
| title_fullStr | Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement |
| title_full_unstemmed | Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement |
| title_short | Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement |
| title_sort | aortic stiffness is related to the ischemic brain injury biomarker n methyl d aspartate receptor antibody levels in aortic valve replacement |
| url | http://dx.doi.org/10.1155/2014/970793 |
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