Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment
BackgroundArteriovenous malformations (AVMs) account for <3% of vascular anomalies. This study aims to present the 10-year experience of a German vascular anomaly center (VAC) with AVMs and evaluate diagnostic imaging for treatment-relevant information for minimally invasive therapy planning....
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Frontiers Media S.A.
2024-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1473685/full |
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| author | Nadja Werba Johannes Ludwig Christel Weiss Felix Struebing Stefan Schoenberg Maliha Sadick |
| author_facet | Nadja Werba Johannes Ludwig Christel Weiss Felix Struebing Stefan Schoenberg Maliha Sadick |
| author_sort | Nadja Werba |
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| description | BackgroundArteriovenous malformations (AVMs) account for <3% of vascular anomalies. This study aims to present the 10-year experience of a German vascular anomaly center (VAC) with AVMs and evaluate diagnostic imaging for treatment-relevant information for minimally invasive therapy planning.Material and methodsA retrospective study including patients from the VAC database with AVMs was conducted. Clinical information from patients' records was evaluated. An additional image reading analysis of the available diagnostic imaging using a 4-point Likert scale, focusing on relevant points for minimally invasive treatment planning, was conducted in 13 patients who had all three magnetic resonance tomography (MRI), computed tomography (CT), and conventional angiography available.ResultsBetween April 2014 and March 2024, 60 patients (60% female, 40% male; 12% Parkes Weber syndrome) with AVMs presented to the VAC. The median age was 36 years (range: 11–78 years). Referral diagnosis was correct in 73.3% of cases. The mean distance to the VAC was 102.5 km (±111.0). The most common locations involved the hand (32%), lower extremity (22%), and pelvis (22%). The most common symptoms were pain (81%), pulsation (64%), and local hyperthermia (62%). Necrosis was significantly more common when the AVM was located in the hand (p = 0.0129) and growth when located in the pelvis (p = 0.0037). Furthermore, cosmetic issues were significantly more frequent when the AVM was located in the head area (p = 0.0333). Most patients presented with Schobinger stage II (57%). Right heart strain was only documented in one case. A total of 47% had undergone invasive therapies before VAC admission. In 30% of cases, further minimally invasive or invasive therapy was required. In the diagnostic imaging evaluation, conventional angiography had the overall best ratings for image quality (median = 1.00; range: 1.00–2.00), NIDUS evaluation median = 1.00; range: 1.00–2.00), and therapy planning (median = 1.00; range: 1.00–1.33).ConclusionOur 10-year experience showed that in patients with AVMs, the correct diagnosis is often made before admission to a specialized VAC. Diagnostic imaging is essential for endovascular treatment planning, with conventional angiography showing superior utility in image quality, NIDUS evaluation, and therapy planning compared to other modalities. |
| format | Article |
| id | doaj-art-b5cfcbb4e9b9449fa32d6eb3d7fd1ead |
| institution | DOAJ |
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| publishDate | 2024-12-01 |
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| spelling | doaj-art-b5cfcbb4e9b9449fa32d6eb3d7fd1ead2025-08-20T02:51:06ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.14736851473685Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessmentNadja Werba0Johannes Ludwig1Christel Weiss2Felix Struebing3Stefan Schoenberg4Maliha Sadick5Clinic for Radiology and Nuclear Medicine, University Medical Centre Mannheim, Mannheim, GermanyClinic for Radiology and Nuclear Medicine, University Medical Centre Mannheim, Mannheim, GermanyDepartment of Medical Statistics, Biomathematics and Information Processing, Medical Faculty Mannheim, Ruprecht-Karls-University of Heidelberg, Heidelberg, GermanyDepartment of Hand, Plastic and Reconstructive Surgery, Burn Center, Berufsgenossenschaft (BG) Trauma Centre, Ludwigshafen, GermanyClinic for Radiology and Nuclear Medicine, University Medical Centre Mannheim, Mannheim, GermanyClinic for Radiology and Nuclear Medicine, University Medical Centre Mannheim, Mannheim, GermanyBackgroundArteriovenous malformations (AVMs) account for <3% of vascular anomalies. This study aims to present the 10-year experience of a German vascular anomaly center (VAC) with AVMs and evaluate diagnostic imaging for treatment-relevant information for minimally invasive therapy planning.Material and methodsA retrospective study including patients from the VAC database with AVMs was conducted. Clinical information from patients' records was evaluated. An additional image reading analysis of the available diagnostic imaging using a 4-point Likert scale, focusing on relevant points for minimally invasive treatment planning, was conducted in 13 patients who had all three magnetic resonance tomography (MRI), computed tomography (CT), and conventional angiography available.ResultsBetween April 2014 and March 2024, 60 patients (60% female, 40% male; 12% Parkes Weber syndrome) with AVMs presented to the VAC. The median age was 36 years (range: 11–78 years). Referral diagnosis was correct in 73.3% of cases. The mean distance to the VAC was 102.5 km (±111.0). The most common locations involved the hand (32%), lower extremity (22%), and pelvis (22%). The most common symptoms were pain (81%), pulsation (64%), and local hyperthermia (62%). Necrosis was significantly more common when the AVM was located in the hand (p = 0.0129) and growth when located in the pelvis (p = 0.0037). Furthermore, cosmetic issues were significantly more frequent when the AVM was located in the head area (p = 0.0333). Most patients presented with Schobinger stage II (57%). Right heart strain was only documented in one case. A total of 47% had undergone invasive therapies before VAC admission. In 30% of cases, further minimally invasive or invasive therapy was required. In the diagnostic imaging evaluation, conventional angiography had the overall best ratings for image quality (median = 1.00; range: 1.00–2.00), NIDUS evaluation median = 1.00; range: 1.00–2.00), and therapy planning (median = 1.00; range: 1.00–1.33).ConclusionOur 10-year experience showed that in patients with AVMs, the correct diagnosis is often made before admission to a specialized VAC. Diagnostic imaging is essential for endovascular treatment planning, with conventional angiography showing superior utility in image quality, NIDUS evaluation, and therapy planning compared to other modalities.https://www.frontiersin.org/articles/10.3389/fmed.2024.1473685/fullvascular anomaliesarteriovenous malformation (AVM)diagnostic imaging analysismagnetic resonance imaging (MRI)computed tomography |
| spellingShingle | Nadja Werba Johannes Ludwig Christel Weiss Felix Struebing Stefan Schoenberg Maliha Sadick Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment Frontiers in Medicine vascular anomalies arteriovenous malformation (AVM) diagnostic imaging analysis magnetic resonance imaging (MRI) computed tomography |
| title | Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment |
| title_full | Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment |
| title_fullStr | Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment |
| title_full_unstemmed | Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment |
| title_short | Extracranial arteriovenous malformations: a 10-year experience at a German vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment |
| title_sort | extracranial arteriovenous malformations a 10 year experience at a german vascular anomaly center and evaluation of diagnostic imaging for endovascular therapy assessment |
| topic | vascular anomalies arteriovenous malformation (AVM) diagnostic imaging analysis magnetic resonance imaging (MRI) computed tomography |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1473685/full |
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