Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis
Periodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/7403042 |
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| author | Jie Zhao Ying-Hui Zhou Ya-Qiong Zhao Yao Feng Fei Yan Zheng-Rong Gao Qin Ye Yun Chen Qiong Liu Li Tan Shao-Hui Zhang Jing Hu Marie Aimee Dusenge Yun-Zhi Feng Yue Guo |
| author_facet | Jie Zhao Ying-Hui Zhou Ya-Qiong Zhao Yao Feng Fei Yan Zheng-Rong Gao Qin Ye Yun Chen Qiong Liu Li Tan Shao-Hui Zhang Jing Hu Marie Aimee Dusenge Yun-Zhi Feng Yue Guo |
| author_sort | Jie Zhao |
| collection | DOAJ |
| description | Periodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to determine the causes of this variation. Twelve males and twenty females (range 50–68 years old) with initial periodontitis provided subgingival plaque samples. 16S rRNA gene sequencing, QIIME-based data processing, and statistical analyses were carried out using several different analytical approaches to detect differences in the oral microbiome between the two groups. Males had higher Chao1 index, observed species, and phylogenetic diversity whole tree values than females. Analysis of β-diversity indicated that the samples were reasonably divided by the gender. The linear discriminant analysis effect size showed that the most representative biomarkers were the genus Haemophilus in males, whereas the dominant bacteria in females were Campylobacter. Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. These data suggest that gender may be a differentiating factor in the microbial composition of subgingival plaques in elderly patients with initial periodontitis. These results could deepen our understanding of the role of gender in the oral microbiota present during initial periodontitis. |
| format | Article |
| id | doaj-art-b5cd2b56105e4cfca5a4748ac1e8fb17 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b5cd2b56105e4cfca5a4748ac1e8fb172025-02-03T06:05:44ZengWileyJournal of Immunology Research2314-71562021-01-01202110.1155/2021/7403042Gender Variations in the Oral Microbiomes of Elderly Patients with Initial PeriodontitisJie Zhao0Ying-Hui Zhou1Ya-Qiong Zhao2Yao Feng3Fei Yan4Zheng-Rong Gao5Qin Ye6Yun Chen7Qiong Liu8Li Tan9Shao-Hui Zhang10Jing Hu11Marie Aimee Dusenge12Yun-Zhi Feng13Yue Guo14Department of StomatologyNational Clinical Research Center for Metabolic DiseasesDepartment of StomatologyDepartment of StomatologyHunan Key Laboratory of Oral Health Research & Hunan 3D Printing Engineering Research Center of Oral Care & Hunan Clinical Research Center of Oral Major Diseases and Oral Health & Xiangya Stomatological Hospital & Xiangya School of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyPeriodontitis is a globally prevalent disease that imposes a functional and aesthetic burden on patients. The oral microbiome influences human health. The aim of this study was at assessing gender variation in the subgingival bacterial microbiome of elderly patients with initial periodontitis and to determine the causes of this variation. Twelve males and twenty females (range 50–68 years old) with initial periodontitis provided subgingival plaque samples. 16S rRNA gene sequencing, QIIME-based data processing, and statistical analyses were carried out using several different analytical approaches to detect differences in the oral microbiome between the two groups. Males had higher Chao1 index, observed species, and phylogenetic diversity whole tree values than females. Analysis of β-diversity indicated that the samples were reasonably divided by the gender. The linear discriminant analysis effect size showed that the most representative biomarkers were the genus Haemophilus in males, whereas the dominant bacteria in females were Campylobacter. Kyoto Encyclopedia of Genes and Genomes analysis showed that predicting changes in the female oral microbiota may be related to the immune system and immune system diseases are the main factor in males. These data suggest that gender may be a differentiating factor in the microbial composition of subgingival plaques in elderly patients with initial periodontitis. These results could deepen our understanding of the role of gender in the oral microbiota present during initial periodontitis.http://dx.doi.org/10.1155/2021/7403042 |
| spellingShingle | Jie Zhao Ying-Hui Zhou Ya-Qiong Zhao Yao Feng Fei Yan Zheng-Rong Gao Qin Ye Yun Chen Qiong Liu Li Tan Shao-Hui Zhang Jing Hu Marie Aimee Dusenge Yun-Zhi Feng Yue Guo Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis Journal of Immunology Research |
| title | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
| title_full | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
| title_fullStr | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
| title_full_unstemmed | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
| title_short | Gender Variations in the Oral Microbiomes of Elderly Patients with Initial Periodontitis |
| title_sort | gender variations in the oral microbiomes of elderly patients with initial periodontitis |
| url | http://dx.doi.org/10.1155/2021/7403042 |
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