Female urethral diverticular carcinoma: a case report and review of the literature
ObjectiveTo investigate the etiology, clinical manifestations, treatment methods, and prognosis of urethral diverticulum cancer to enhance understanding of this disease.MethodsThis paper reports a case of urethral diverticulum cancer with “hematuria and dysuria” as the main clinical manifestations....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1503116/full |
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| author | Dan Li Fan Hua Meng Xu Yang |
| author_facet | Dan Li Fan Hua Meng Xu Yang |
| author_sort | Dan Li |
| collection | DOAJ |
| description | ObjectiveTo investigate the etiology, clinical manifestations, treatment methods, and prognosis of urethral diverticulum cancer to enhance understanding of this disease.MethodsThis paper reports a case of urethral diverticulum cancer with “hematuria and dysuria” as the main clinical manifestations. The case is discussed in conjunction with relevant literature.ResultsThe patient initially presented to the gynecology department due to postmenopausal bleeding but was not diagnosed with the disease. Subsequently, the patient developed hematuria and dysuria and was referred to the urology department. MRI indicated urethral diverticulum-like changes with suspected tumorous lesions. Cystourethroscopic biopsy confirmed urethral diverticulum cancer. The patient underwent urethrectomy, and postoperative pathological diagnosis was poorly differentiated urothelial adenocarcinoma.ConclusionUrethral diverticulum cancer is a rare and highly aggressive malignant tumor of the urethra with a poor prognosis. The onset of urethral diverticulum cancer is concealed, and its clinical manifestations are nonspecific and diverse. Preoperative diagnosis is challenging, and imaging studies and cystourethroscopy are the primary preoperative diagnostic methods for urethral diverticulum cancer. Pathology and immunohistochemistry serve as the basis for confirmation of diagnosis. Currently, there is no unified treatment protocol for female urethral diverticulum cancer internationally. For female patients with urethral diverticulum cancer without distant metastasis, surgery remains the primary treatment. For patients with distant metastasis, a combination of surgery, chemotherapy, and radiotherapy may be considered.Genetic testing and targeted immunotherapy offer new approaches for future treatment. |
| format | Article |
| id | doaj-art-b5cd051a08bb41c9a0860f448c32749c |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-b5cd051a08bb41c9a0860f448c32749c2025-01-27T11:50:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15031161503116Female urethral diverticular carcinoma: a case report and review of the literatureDan Li0Fan Hua Meng1Xu Yang2Gynecology Department, Chengdu Fifth People’s Hospital, Chengdu, ChinaUrology Department, The First Hospital of Fuyang District, Hangzhou, ChinaGynecology Department, Chengdu Fifth People’s Hospital, Chengdu, ChinaObjectiveTo investigate the etiology, clinical manifestations, treatment methods, and prognosis of urethral diverticulum cancer to enhance understanding of this disease.MethodsThis paper reports a case of urethral diverticulum cancer with “hematuria and dysuria” as the main clinical manifestations. The case is discussed in conjunction with relevant literature.ResultsThe patient initially presented to the gynecology department due to postmenopausal bleeding but was not diagnosed with the disease. Subsequently, the patient developed hematuria and dysuria and was referred to the urology department. MRI indicated urethral diverticulum-like changes with suspected tumorous lesions. Cystourethroscopic biopsy confirmed urethral diverticulum cancer. The patient underwent urethrectomy, and postoperative pathological diagnosis was poorly differentiated urothelial adenocarcinoma.ConclusionUrethral diverticulum cancer is a rare and highly aggressive malignant tumor of the urethra with a poor prognosis. The onset of urethral diverticulum cancer is concealed, and its clinical manifestations are nonspecific and diverse. Preoperative diagnosis is challenging, and imaging studies and cystourethroscopy are the primary preoperative diagnostic methods for urethral diverticulum cancer. Pathology and immunohistochemistry serve as the basis for confirmation of diagnosis. Currently, there is no unified treatment protocol for female urethral diverticulum cancer internationally. For female patients with urethral diverticulum cancer without distant metastasis, surgery remains the primary treatment. For patients with distant metastasis, a combination of surgery, chemotherapy, and radiotherapy may be considered.Genetic testing and targeted immunotherapy offer new approaches for future treatment.https://www.frontiersin.org/articles/10.3389/fonc.2024.1503116/fullcancerdiverticulumurethraclinical manifestationstreatment methods |
| spellingShingle | Dan Li Fan Hua Meng Xu Yang Female urethral diverticular carcinoma: a case report and review of the literature Frontiers in Oncology cancer diverticulum urethra clinical manifestations treatment methods |
| title | Female urethral diverticular carcinoma: a case report and review of the literature |
| title_full | Female urethral diverticular carcinoma: a case report and review of the literature |
| title_fullStr | Female urethral diverticular carcinoma: a case report and review of the literature |
| title_full_unstemmed | Female urethral diverticular carcinoma: a case report and review of the literature |
| title_short | Female urethral diverticular carcinoma: a case report and review of the literature |
| title_sort | female urethral diverticular carcinoma a case report and review of the literature |
| topic | cancer diverticulum urethra clinical manifestations treatment methods |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1503116/full |
| work_keys_str_mv | AT danli femaleurethraldiverticularcarcinomaacasereportandreviewoftheliterature AT fanhuameng femaleurethraldiverticularcarcinomaacasereportandreviewoftheliterature AT xuyang femaleurethraldiverticularcarcinomaacasereportandreviewoftheliterature |