The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review
Dementia, particularly Alzheimer's disease (AD), is a growing global health concern, with an estimated 50 million people affected worldwide. The prevalence of AD is projected to increase significantly with aging populations. Despite the absence of a cure, early intervention during the prodroma...
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| Format: | Article |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57782 |
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| author | Julia Lachowska Karolina Senior Jerzy Smandek Maja Mielczarek Paulina Sroczyńska Jan Sroczyński |
| author_facet | Julia Lachowska Karolina Senior Jerzy Smandek Maja Mielczarek Paulina Sroczyńska Jan Sroczyński |
| author_sort | Julia Lachowska |
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Dementia, particularly Alzheimer's disease (AD), is a growing global health concern, with an estimated 50 million people affected worldwide. The prevalence of AD is projected to increase significantly with aging populations. Despite the absence of a cure, early intervention during the prodromal phase can slow the progression of AD, highlighting the importance of identifying modifiable risk and protective factors. Physical inactivity is one of the leading modifiable risk factors, contributing to approximately 40% of dementia cases. This review explores the role of physical exercise, particularly resistance training (RET), aerobic exercises, and dance movement interventions (DMI), as therapeutic approaches for AD prevention and treatment. Evidence suggests that regular physical activity enhances cognitive function, reduces neuroinflammation, improves brain structure, and supports neuroplasticity. Both RET and aerobic exercise have been shown to delay the onset of cognitive decline, with RET also reducing amyloid plaque formation and promoting neuroprotection. DMI further benefits individuals with AD by improving cognitive function, mood regulation, social interaction, and physical coordination. Additionally, the review examines the relationship between obesity and AD. Although obesity is traditionally seen as a risk factor for cognitive decline, recent studies suggest that obesity in late life may have protective effects, potentially due to factors like lower amyloid-beta levels and larger hippocampal volume. This review emphasizes the importance of physical exercise and its potential to mitigate cognitive decline and improve quality of life in individuals at risk of or living with Alzheimer’s disease.
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| format | Article |
| id | doaj-art-b5cb71087c2b4339a9ecd31cdbc811a5 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-b5cb71087c2b4339a9ecd31cdbc811a52025-01-28T08:25:02ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2024.37.57782The Effect of Physical Activity on Alzheimer’s Disease - Systematic ReviewJulia Lachowska0https://orcid.org/0000-0002-9627-7615Karolina Senior1https://orcid.org/0009-0005-2813-2878Jerzy Smandek2https://orcid.org/0009-0009-1487-4351Maja Mielczarek3https://orcid.org/0009-0007-9838-2295Paulina Sroczyńska4https://orcid.org/0009-0008-7250-2014Jan Sroczyński5https://orcid.org/0009-0000-0011-24814th Military Clinical Hospital in Wroclaw ul.Weigla 5; 53-114 Wroclaw, PolandLower Silesian Specialist Hospital named in after T. Marciniak ul. Gen. Augusta Emila Fieldorfa 2; 54-049 WroclawHealth Care Complex in Oława ul. Baczyńskiego 1, 55-200, OławaProvincial Specialist Hospital in Wroclaw ul.Kamieńskiego 73A; 51-124 Wroclaw, PolandPrzychodnia Nowy Medyk Szkolna 2; 46-100 Kowalowice, PolandUniversity of Radom named after K. Pulaski, Faculty of Medical Sciences and Health Sciences. B. Chrobrego 27; 26-600 Radom, Poland Dementia, particularly Alzheimer's disease (AD), is a growing global health concern, with an estimated 50 million people affected worldwide. The prevalence of AD is projected to increase significantly with aging populations. Despite the absence of a cure, early intervention during the prodromal phase can slow the progression of AD, highlighting the importance of identifying modifiable risk and protective factors. Physical inactivity is one of the leading modifiable risk factors, contributing to approximately 40% of dementia cases. This review explores the role of physical exercise, particularly resistance training (RET), aerobic exercises, and dance movement interventions (DMI), as therapeutic approaches for AD prevention and treatment. Evidence suggests that regular physical activity enhances cognitive function, reduces neuroinflammation, improves brain structure, and supports neuroplasticity. Both RET and aerobic exercise have been shown to delay the onset of cognitive decline, with RET also reducing amyloid plaque formation and promoting neuroprotection. DMI further benefits individuals with AD by improving cognitive function, mood regulation, social interaction, and physical coordination. Additionally, the review examines the relationship between obesity and AD. Although obesity is traditionally seen as a risk factor for cognitive decline, recent studies suggest that obesity in late life may have protective effects, potentially due to factors like lower amyloid-beta levels and larger hippocampal volume. This review emphasizes the importance of physical exercise and its potential to mitigate cognitive decline and improve quality of life in individuals at risk of or living with Alzheimer’s disease. https://apcz.umk.pl/QS/article/view/57782Alzheimer’s diseasephysical activitymodifiable risk factorsresistance exercise trainingaerobic exercise |
| spellingShingle | Julia Lachowska Karolina Senior Jerzy Smandek Maja Mielczarek Paulina Sroczyńska Jan Sroczyński The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review Quality in Sport Alzheimer’s disease physical activity modifiable risk factors resistance exercise training aerobic exercise |
| title | The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review |
| title_full | The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review |
| title_fullStr | The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review |
| title_full_unstemmed | The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review |
| title_short | The Effect of Physical Activity on Alzheimer’s Disease - Systematic Review |
| title_sort | effect of physical activity on alzheimer s disease systematic review |
| topic | Alzheimer’s disease physical activity modifiable risk factors resistance exercise training aerobic exercise |
| url | https://apcz.umk.pl/QS/article/view/57782 |
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