Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry

Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry

Abstract Lipid nanoparticle RNA (LNP-RNA) formulations are used for the delivery of vaccines and other therapies. RNA molecules are encapsulated within their interior through electrostatic interactions with positively charged lipids. The identity of the lipids that present at their surface play a ro...

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Main Authors: Anna M. Kotowska, Michael Fay, Julie A. Watts, Ian S. Gilmore, David J. Scurr, Alaina Howe, Vladimir Capka, Corey E. Perez, Devin Doud, Siddharth Patel, Mark Umbarger, Robert Langer, Morgan R. Alexander
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01526-x
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https://doi.org/10.1038/s42004-025-01526-x

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