Diagnostic delay of myositis: protocol for an integrated systematic review
Introduction Idiopathic inflammatory myopathies (IIM). described as ‘inflammatory myositis’, are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. Its complex characteristics with lack of accurate diagnostic tests, unified classification system...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-06-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/6/e060312.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583737504694272 |
|---|---|
| author | Christine Phillips Matthew Cook Anne Parkinson Jane Desborough Tergel Namsrai Anita Chalmers Christine Lowe |
| author_facet | Christine Phillips Matthew Cook Anne Parkinson Jane Desborough Tergel Namsrai Anita Chalmers Christine Lowe |
| author_sort | Christine Phillips |
| collection | DOAJ |
| description | Introduction Idiopathic inflammatory myopathies (IIM). described as ‘inflammatory myositis’, are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. Its complex characteristics with lack of accurate diagnostic tests, unified classification system and comprehensive widely used diagnostic criteria could lead to diagnostic delay. This study will review diagnostic delay in myositis and provide an overview and clearer insight of patients’ experiences, causes and consequences of diagnostic delay in myositis.Methods and analysis The literature source will be a systematic search of PubMed/MEDLINE, Scopus, ProQuest and sources of grey literature, conducted from database inception to December 2021 without restrictions on publication date. All study types (qualitative and quantitative) except review articles, examining diagnostic delay, incorrect diagnosis, missed diagnosis or slow diagnosis of all types of myositis in all ages will be included. Evidence of patients’ experiences associated with diagnostic delay will also be examined. Studies in languages other than English, German and Indonesian will be excluded. Outcomes will be diagnostic delay time, patients’ experiences, and causes and consequences associated with diagnostic delay in myositis. Two review authors will independently screen the titles and abstracts of search results against the inclusion criteria. The Mixed Methods Appraisal Tool (MMAT) will be used to appraise selected studies. Two independent authors will extract data using a prepiloted data extraction tool. If sufficient quantitative data is available, a meta-analysis will be conducted along with subgroup analysis including pooled diagnostic delay in each type of myositis. Qualitative data will be analysed in line with meta-aggregation methods. If data is insufficient, a narrative synthesis will be conducted.Ethics and dissemination As this work is a systematic review, ethical approval was not required. Findings of the study will be disseminated through publications in peer-reviewed journals, conferences and symposia.PROSPERO registration number CRD42022289830. |
| format | Article |
| id | doaj-art-b5bfa07a0096414d9ac9ebbdb0289e5e |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-b5bfa07a0096414d9ac9ebbdb0289e5e2025-01-28T08:40:15ZengBMJ Publishing GroupBMJ Open2044-60552022-06-0112610.1136/bmjopen-2021-060312Diagnostic delay of myositis: protocol for an integrated systematic reviewChristine Phillips0Matthew Cook1Anne Parkinson2Jane Desborough3Tergel Namsrai4Anita Chalmers5Christine Lowe6Australian National University, Canberra, Australian Capital Territory, AustraliaThe John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, AustraliaAustralian Primary Health Care Research Institute, Australian National University, Canberra, Australian Capital Territory, AustraliaDepartment of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, AustraliaNational Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, AustraliaNational Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, AustraliaNational Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, AustraliaIntroduction Idiopathic inflammatory myopathies (IIM). described as ‘inflammatory myositis’, are a heterogeneous group of rare muscular autoimmune diseases characterised by skeletal muscle inflammation. Its complex characteristics with lack of accurate diagnostic tests, unified classification system and comprehensive widely used diagnostic criteria could lead to diagnostic delay. This study will review diagnostic delay in myositis and provide an overview and clearer insight of patients’ experiences, causes and consequences of diagnostic delay in myositis.Methods and analysis The literature source will be a systematic search of PubMed/MEDLINE, Scopus, ProQuest and sources of grey literature, conducted from database inception to December 2021 without restrictions on publication date. All study types (qualitative and quantitative) except review articles, examining diagnostic delay, incorrect diagnosis, missed diagnosis or slow diagnosis of all types of myositis in all ages will be included. Evidence of patients’ experiences associated with diagnostic delay will also be examined. Studies in languages other than English, German and Indonesian will be excluded. Outcomes will be diagnostic delay time, patients’ experiences, and causes and consequences associated with diagnostic delay in myositis. Two review authors will independently screen the titles and abstracts of search results against the inclusion criteria. The Mixed Methods Appraisal Tool (MMAT) will be used to appraise selected studies. Two independent authors will extract data using a prepiloted data extraction tool. If sufficient quantitative data is available, a meta-analysis will be conducted along with subgroup analysis including pooled diagnostic delay in each type of myositis. Qualitative data will be analysed in line with meta-aggregation methods. If data is insufficient, a narrative synthesis will be conducted.Ethics and dissemination As this work is a systematic review, ethical approval was not required. Findings of the study will be disseminated through publications in peer-reviewed journals, conferences and symposia.PROSPERO registration number CRD42022289830.https://bmjopen.bmj.com/content/12/6/e060312.full |
| spellingShingle | Christine Phillips Matthew Cook Anne Parkinson Jane Desborough Tergel Namsrai Anita Chalmers Christine Lowe Diagnostic delay of myositis: protocol for an integrated systematic review BMJ Open |
| title | Diagnostic delay of myositis: protocol for an integrated systematic review |
| title_full | Diagnostic delay of myositis: protocol for an integrated systematic review |
| title_fullStr | Diagnostic delay of myositis: protocol for an integrated systematic review |
| title_full_unstemmed | Diagnostic delay of myositis: protocol for an integrated systematic review |
| title_short | Diagnostic delay of myositis: protocol for an integrated systematic review |
| title_sort | diagnostic delay of myositis protocol for an integrated systematic review |
| url | https://bmjopen.bmj.com/content/12/6/e060312.full |
| work_keys_str_mv | AT christinephillips diagnosticdelayofmyositisprotocolforanintegratedsystematicreview AT matthewcook diagnosticdelayofmyositisprotocolforanintegratedsystematicreview AT anneparkinson diagnosticdelayofmyositisprotocolforanintegratedsystematicreview AT janedesborough diagnosticdelayofmyositisprotocolforanintegratedsystematicreview AT tergelnamsrai diagnosticdelayofmyositisprotocolforanintegratedsystematicreview AT anitachalmers diagnosticdelayofmyositisprotocolforanintegratedsystematicreview AT christinelowe diagnosticdelayofmyositisprotocolforanintegratedsystematicreview |