Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan
Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/959271 |
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| author | Jun Yamada Kunikazu Tsuji Kazumasa Miyatake Yu Matsukura Kahaer Abula Makiko Inoue Ichiro Sekiya Takeshi Muneta |
| author_facet | Jun Yamada Kunikazu Tsuji Kazumasa Miyatake Yu Matsukura Kahaer Abula Makiko Inoue Ichiro Sekiya Takeshi Muneta |
| author_sort | Jun Yamada |
| collection | DOAJ |
| description | Activins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of follistatin in a carrageenan-induced mouse arthritis model. Synovitis induced by intra-articular injection of carrageenan was significantly alleviated by preinjection with follistatin. Macrophage infiltration into the synovial membrane was significantly reduced in the presence of follistatin. In addition, follistatin inhibited proteoglycan erosion induced by carrageenan in articular cartilage. These data indicate that activin-follistatin signaling is involved in joint inflammation and cartilage homeostasis. Our data suggest that follistatin can be a new therapeutic target for inflammation-induced articular cartilage degeneration. |
| format | Article |
| id | doaj-art-b5b400a66ba54957a1628dc174306574 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-b5b400a66ba54957a1628dc1743065742025-02-03T01:26:47ZengWileyInternational Journal of Inflammation2090-80402042-00992014-01-01201410.1155/2014/959271959271Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by CarrageenanJun Yamada0Kunikazu Tsuji1Kazumasa Miyatake2Yu Matsukura3Kahaer Abula4Makiko Inoue5Ichiro Sekiya6Takeshi Muneta7Department of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, JapanDepartment of Cartilage Regeneration, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, JapanDepartment of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, JapanDepartment of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, JapanDepartment of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, JapanDepartment of Plastic and Reconstructive Surgery, Tokyo Medical and Dental University, Tokyo 113-8519, JapanCenter for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, JapanDepartment of Joint Surgery and Sports Medicine, Tokyo Medical and Dental University, Tokyo 113-8519, JapanActivins are proinflammatory cytokines which belong to the TGFβ superfamily. Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. To test this hypothesis, we examined the effects of follistatin in a carrageenan-induced mouse arthritis model. Synovitis induced by intra-articular injection of carrageenan was significantly alleviated by preinjection with follistatin. Macrophage infiltration into the synovial membrane was significantly reduced in the presence of follistatin. In addition, follistatin inhibited proteoglycan erosion induced by carrageenan in articular cartilage. These data indicate that activin-follistatin signaling is involved in joint inflammation and cartilage homeostasis. Our data suggest that follistatin can be a new therapeutic target for inflammation-induced articular cartilage degeneration.http://dx.doi.org/10.1155/2014/959271 |
| spellingShingle | Jun Yamada Kunikazu Tsuji Kazumasa Miyatake Yu Matsukura Kahaer Abula Makiko Inoue Ichiro Sekiya Takeshi Muneta Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan International Journal of Inflammation |
| title | Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan |
| title_full | Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan |
| title_fullStr | Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan |
| title_full_unstemmed | Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan |
| title_short | Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan |
| title_sort | follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan |
| url | http://dx.doi.org/10.1155/2014/959271 |
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