The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis
Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Carnosic acid (CA) is a major antioxidant component of rosemary and sage. Herein, we investigated the protective effects of dietary CA on dextran sodium sulfate (DS...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453022002221 |
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| author | Changhui Du Zhenjie Li Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun Xiaoqing Yu Wei Chen Hang Xiao Xian Wu Xuexiang Chen |
| author_facet | Changhui Du Zhenjie Li Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun Xiaoqing Yu Wei Chen Hang Xiao Xian Wu Xuexiang Chen |
| author_sort | Changhui Du |
| collection | DOAJ |
| description | Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Carnosic acid (CA) is a major antioxidant component of rosemary and sage. Herein, we investigated the protective effects of dietary CA on dextran sodium sulfate (DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota. We found that CA effectively attenuated DSS-stimulated colitis in mice, as evidenced by reduced disease activity index (DAI), and systemic and colonic inflammation. Additionally, CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice. Moreover, Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species. Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis. Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans. |
| format | Article |
| id | doaj-art-b5acd50fc25243a2b9b010d5fa9985b9 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-b5acd50fc25243a2b9b010d5fa9985b92025-02-03T11:09:30ZengTsinghua University PressFood Science and Human Wellness2213-45302023-07-0112412121223The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysisChanghui Du0Zhenjie Li1Jing Zhang2Ni Yin3Lirong Tang4Jie Li5Jingyin Sun6Xiaoqing Yu7Wei Chen8Hang Xiao9Xian Wu10Xuexiang Chen11School of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaSchool of Public Health, Guangzhou Medical University, Guangzhou 510642, ChinaDepartment of Information Systems and Analytics, Miami University, Oxford 45056, USADepartment of Food Science, University of Massachusetts, Amherst 01003, USADepartment of Kinesiology, Nutrition, and Health, Miami University, Oxford 45056, USA; Corresponding authors.School of Public Health, Guangzhou Medical University, Guangzhou 510642, China; Corresponding authors.Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Carnosic acid (CA) is a major antioxidant component of rosemary and sage. Herein, we investigated the protective effects of dietary CA on dextran sodium sulfate (DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota. We found that CA effectively attenuated DSS-stimulated colitis in mice, as evidenced by reduced disease activity index (DAI), and systemic and colonic inflammation. Additionally, CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice. Moreover, Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species. Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis. Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans.http://www.sciencedirect.com/science/article/pii/S2213453022002221Carnosic acidInflammatory bowel diseasesColitisGut microbiotaMetabolites |
| spellingShingle | Changhui Du Zhenjie Li Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun Xiaoqing Yu Wei Chen Hang Xiao Xian Wu Xuexiang Chen The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis Food Science and Human Wellness Carnosic acid Inflammatory bowel diseases Colitis Gut microbiota Metabolites |
| title | The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis |
| title_full | The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis |
| title_fullStr | The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis |
| title_full_unstemmed | The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis |
| title_short | The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis |
| title_sort | protective effect of carnosic acid on dextran sulfate sodium induced colitis based on metabolomics and gut microbiota analysis |
| topic | Carnosic acid Inflammatory bowel diseases Colitis Gut microbiota Metabolites |
| url | http://www.sciencedirect.com/science/article/pii/S2213453022002221 |
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