Role of Hypothalamus in Acupuncture’s Effects

The significant correlation between ancient medicinal practices and brain function marks a revolutionary frontier in the field of neuroscience. Acupuncture, a traditional oriental medicine, can affect brain regions, such as the hypothalamus, anterior cingulate, posterior cingulate, and hippocampus,...

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Main Authors: Ryan Bae, Hyung Kyu Kim, Baoji Lu, Jing Ma, Juping Xing, Hee Young Kim
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Brain Sciences
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Online Access:https://www.mdpi.com/2076-3425/15/1/72
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author Ryan Bae
Hyung Kyu Kim
Baoji Lu
Jing Ma
Juping Xing
Hee Young Kim
author_facet Ryan Bae
Hyung Kyu Kim
Baoji Lu
Jing Ma
Juping Xing
Hee Young Kim
author_sort Ryan Bae
collection DOAJ
description The significant correlation between ancient medicinal practices and brain function marks a revolutionary frontier in the field of neuroscience. Acupuncture, a traditional oriental medicine, can affect brain regions, such as the hypothalamus, anterior cingulate, posterior cingulate, and hippocampus, and produces specific therapeutic effects, such as pain relief, suppression of hypertension, and alleviation of drug addiction. Among the brain regions, the hypothalamus, a small yet critical region in the brain, plays a pivotal role in maintaining homeostasis by regulating a wide array of physiological processes, including stress responses, energy balance, and pain modulation. Emerging evidence suggests that acupuncture may exert its therapeutic effects by modulating the activity of the hypothalamus and its associated neural circuits, particularly in relation to pain, stress, and metabolic regulation. Thus, we conducted a comprehensive review of past and current research on the role of the hypothalamus in mediating the therapeutic effects of acupuncture.
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spelling doaj-art-b5a438cff4594fd4b57a4e0fa36a656c2025-01-24T13:25:53ZengMDPI AGBrain Sciences2076-34252025-01-011517210.3390/brainsci15010072Role of Hypothalamus in Acupuncture’s EffectsRyan Bae0Hyung Kyu Kim1Baoji Lu2Jing Ma3Juping Xing4Hee Young Kim5Morrissey College of Arts and Sciences, Boston College, Boston, MA 02467, USADepartment of Physiology, College of Medicine, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Physiology, College of Medicine, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Physiology, College of Medicine, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Physiology, College of Medicine, Yonsei University, Seoul 03722, Republic of KoreaDepartment of Physiology, College of Medicine, Yonsei University, Seoul 03722, Republic of KoreaThe significant correlation between ancient medicinal practices and brain function marks a revolutionary frontier in the field of neuroscience. Acupuncture, a traditional oriental medicine, can affect brain regions, such as the hypothalamus, anterior cingulate, posterior cingulate, and hippocampus, and produces specific therapeutic effects, such as pain relief, suppression of hypertension, and alleviation of drug addiction. Among the brain regions, the hypothalamus, a small yet critical region in the brain, plays a pivotal role in maintaining homeostasis by regulating a wide array of physiological processes, including stress responses, energy balance, and pain modulation. Emerging evidence suggests that acupuncture may exert its therapeutic effects by modulating the activity of the hypothalamus and its associated neural circuits, particularly in relation to pain, stress, and metabolic regulation. Thus, we conducted a comprehensive review of past and current research on the role of the hypothalamus in mediating the therapeutic effects of acupuncture.https://www.mdpi.com/2076-3425/15/1/72acupuncturelateral hypothalamic areanucleus accumbensdopamineorexinhypocretin
spellingShingle Ryan Bae
Hyung Kyu Kim
Baoji Lu
Jing Ma
Juping Xing
Hee Young Kim
Role of Hypothalamus in Acupuncture’s Effects
Brain Sciences
acupuncture
lateral hypothalamic area
nucleus accumbens
dopamine
orexin
hypocretin
title Role of Hypothalamus in Acupuncture’s Effects
title_full Role of Hypothalamus in Acupuncture’s Effects
title_fullStr Role of Hypothalamus in Acupuncture’s Effects
title_full_unstemmed Role of Hypothalamus in Acupuncture’s Effects
title_short Role of Hypothalamus in Acupuncture’s Effects
title_sort role of hypothalamus in acupuncture s effects
topic acupuncture
lateral hypothalamic area
nucleus accumbens
dopamine
orexin
hypocretin
url https://www.mdpi.com/2076-3425/15/1/72
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