An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice
Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function—protective genes that confer strong resistance to hearing loss. Previousl...
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| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8889264 |
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| author | Qing Yin Zheng Lihong Kui Fuyi Xu Tihua Zheng Bo Li Melinda McCarty Zehua Sun Aizheng Zhang Luying Liu Athena Starlard-Davenport Ruben Stepanyan Bo Hua Hu Lu Lu |
| author_facet | Qing Yin Zheng Lihong Kui Fuyi Xu Tihua Zheng Bo Li Melinda McCarty Zehua Sun Aizheng Zhang Luying Liu Athena Starlard-Davenport Ruben Stepanyan Bo Hua Hu Lu Lu |
| author_sort | Qing Yin Zheng |
| collection | DOAJ |
| description | Inbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function—protective genes that confer strong resistance to hearing loss. Previously, we reported that C57BL/6J (B6) and DBA/2J (D2) strains share a common hearing loss allele in Cdh23. The cadherin 23 (Cdh23) gene is a key contributor to early-onset hearing loss in humans. In this study, we tested hearing across a large family of 54 BXD strains generated from B6 to D2 crosses. Five of 54 strains maintain the normal threshold (20 dB SPL) even at 2 years old—an age at which both parental strains are essentially deaf. Further analyses revealed an age-related hearing protection (ahp) locus on chromosome 16 (Chr 16) at 57~76 Mb with a maximum LOD of 5.7. A small number of BXD strains at 2 years with good hearing correspond roughly to the percentage of humans who have good hearing at 90 years old. Further studies to define candidate genes in the ahp locus and related molecular mechanisms involved in age-related resilience or resistance to AHL are warranted. |
| format | Article |
| id | doaj-art-b5a1f626f4c64d5ca37de4dcbcd4d318 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b5a1f626f4c64d5ca37de4dcbcd4d3182025-02-03T06:06:29ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88892648889264An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain MiceQing Yin Zheng0Lihong Kui1Fuyi Xu2Tihua Zheng3Bo Li4Melinda McCarty5Zehua Sun6Aizheng Zhang7Luying Liu8Athena Starlard-Davenport9Ruben Stepanyan10Bo Hua Hu11Lu Lu12Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USADepartment of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USADepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38106, USAHearing and Speech Rehabilitation Institute, College of Special Education, Binzhou Medical University, Yantai, ChinaHearing and Speech Rehabilitation Institute, College of Special Education, Binzhou Medical University, Yantai, ChinaDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38106, USADepartment of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USADepartment of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USADepartment of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USADepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38106, USADepartment of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USACenter for Hearing and Deafness, University at Buffalo, NY 14214, USADepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38106, USAInbred mouse models are widely used to study age-related hearing loss (AHL). Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function—protective genes that confer strong resistance to hearing loss. Previously, we reported that C57BL/6J (B6) and DBA/2J (D2) strains share a common hearing loss allele in Cdh23. The cadherin 23 (Cdh23) gene is a key contributor to early-onset hearing loss in humans. In this study, we tested hearing across a large family of 54 BXD strains generated from B6 to D2 crosses. Five of 54 strains maintain the normal threshold (20 dB SPL) even at 2 years old—an age at which both parental strains are essentially deaf. Further analyses revealed an age-related hearing protection (ahp) locus on chromosome 16 (Chr 16) at 57~76 Mb with a maximum LOD of 5.7. A small number of BXD strains at 2 years with good hearing correspond roughly to the percentage of humans who have good hearing at 90 years old. Further studies to define candidate genes in the ahp locus and related molecular mechanisms involved in age-related resilience or resistance to AHL are warranted.http://dx.doi.org/10.1155/2020/8889264 |
| spellingShingle | Qing Yin Zheng Lihong Kui Fuyi Xu Tihua Zheng Bo Li Melinda McCarty Zehua Sun Aizheng Zhang Luying Liu Athena Starlard-Davenport Ruben Stepanyan Bo Hua Hu Lu Lu An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice Neural Plasticity |
| title | An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice |
| title_full | An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice |
| title_fullStr | An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice |
| title_full_unstemmed | An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice |
| title_short | An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice |
| title_sort | age related hearing protection locus on chromosome 16 of bxd strain mice |
| url | http://dx.doi.org/10.1155/2020/8889264 |
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