Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G

Effective long-term treatment with moss-produced factor H by overcoming the antibody response in a mouse model of C3G

Complement-associated disorders are caused by the dysregulation and disbalance of the complement system, especially excessive activation. Most drugs that target the complement system are designed to inhibit the complement pathway at either the proximal or terminal levels. The use of a natural comple...

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Bibliographic Details
Main Authors: Todor Tschongov, Swagata Konwar, Jessika Kleindienst, Paulina Dabrowska-Schlepp, Andreas Busch, Andreas Schaaf, Christoph Schell, Manuel Rogg, Karsten Häffner
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
C3 glomerulopathy
complement system
protein replacement therapy
complement factor H
anti-drug antibodies
B-cell depletion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1535547/full
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