Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis
ObjectiveTo systematically evaluate the differences in the efficacy of commonly used topical commercial Chinese polyherbal preparations (CCPPs) for vulvovaginal candidiasis (VVC), and to provide evidence-based reference for clinical drug regimens.MethodsComputer searched major Chinese and English li...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1484325/full |
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| author | Lizheng Wu Shangwen Jing Na Li Dandan Cao Fangli Pei Yantong Luo Xiaoxin Chen Yingjie Huang Cheng Zeng |
| author_facet | Lizheng Wu Shangwen Jing Na Li Dandan Cao Fangli Pei Yantong Luo Xiaoxin Chen Yingjie Huang Cheng Zeng |
| author_sort | Lizheng Wu |
| collection | DOAJ |
| description | ObjectiveTo systematically evaluate the differences in the efficacy of commonly used topical commercial Chinese polyherbal preparations (CCPPs) for vulvovaginal candidiasis (VVC), and to provide evidence-based reference for clinical drug regimens.MethodsComputer searched major Chinese and English literature databases, and collected randomized controlled trials (RCTs) of external use of CCPPs combined with conventional treatment (CT, test group) versus CT alone (control group) in patients with VVC. After screening the literature, the quality of the included studies was assessed using the risk of bias assessment tool recommended in 5.3 of the Cochrane Handbook. Outcome data for each outcome measure were extracted and a network meta-analysis was performed using Stata 15.0.ResultsA total of 74 RCTs with a total of 8,151 patients were included, nine interventions were involved. The results of network meta-analysis showed that, Fufang Shajiziyou suppository combined with CT was more effective in improving the negative conversion rate and controlling the recurrence rate of Candida albicans. Kangfu gel combined with CT had the better effect in relieving pruritus. Baofukang suppository combined with CT was the most effective in reducing leukorrhea. Fufukang spray combined with CT had fewer adverse reactions.ConclusionThe addition of CCPPs to CT may acquire a better curative effect in patients with VVC and external does not significantly increase the occurrence of adverse reactions. However, due to the low quality of the included literature, larger-scale, higher-quality clinical studies are still needed.Systematic Review RegistrationPROSPERO, NO: CRD42023410244. |
| format | Article |
| id | doaj-art-b5a0c07eb59945f2b9fe17475ebe5987 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b5a0c07eb59945f2b9fe17475ebe59872025-02-03T06:33:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.14843251484325Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysisLizheng Wu0Shangwen Jing1Na Li2Dandan Cao3Fangli Pei4Yantong Luo5Xiaoxin Chen6Yingjie Huang7Cheng Zeng8The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe Basic Medicine College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaAffiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, ChinaDepartment of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaThe First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaDepartment of Gynecology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, ChinaObjectiveTo systematically evaluate the differences in the efficacy of commonly used topical commercial Chinese polyherbal preparations (CCPPs) for vulvovaginal candidiasis (VVC), and to provide evidence-based reference for clinical drug regimens.MethodsComputer searched major Chinese and English literature databases, and collected randomized controlled trials (RCTs) of external use of CCPPs combined with conventional treatment (CT, test group) versus CT alone (control group) in patients with VVC. After screening the literature, the quality of the included studies was assessed using the risk of bias assessment tool recommended in 5.3 of the Cochrane Handbook. Outcome data for each outcome measure were extracted and a network meta-analysis was performed using Stata 15.0.ResultsA total of 74 RCTs with a total of 8,151 patients were included, nine interventions were involved. The results of network meta-analysis showed that, Fufang Shajiziyou suppository combined with CT was more effective in improving the negative conversion rate and controlling the recurrence rate of Candida albicans. Kangfu gel combined with CT had the better effect in relieving pruritus. Baofukang suppository combined with CT was the most effective in reducing leukorrhea. Fufukang spray combined with CT had fewer adverse reactions.ConclusionThe addition of CCPPs to CT may acquire a better curative effect in patients with VVC and external does not significantly increase the occurrence of adverse reactions. However, due to the low quality of the included literature, larger-scale, higher-quality clinical studies are still needed.Systematic Review RegistrationPROSPERO, NO: CRD42023410244.https://www.frontiersin.org/articles/10.3389/fphar.2025.1484325/fullvulvovaginal candidiasiscommercial Chinese polyherbal preparation (CCPP)Chinese patent medicinetraditional Chinese medicine (TCM)anti-fungal drugsnetwork meta-analysis |
| spellingShingle | Lizheng Wu Shangwen Jing Na Li Dandan Cao Fangli Pei Yantong Luo Xiaoxin Chen Yingjie Huang Cheng Zeng Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis Frontiers in Pharmacology vulvovaginal candidiasis commercial Chinese polyherbal preparation (CCPP) Chinese patent medicine traditional Chinese medicine (TCM) anti-fungal drugs network meta-analysis |
| title | Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis |
| title_full | Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis |
| title_fullStr | Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis |
| title_full_unstemmed | Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis |
| title_short | Comparative efficacy of topical commercial Chinese polyherbal preparation for vulvovaginal candidiasis: a network meta-analysis |
| title_sort | comparative efficacy of topical commercial chinese polyherbal preparation for vulvovaginal candidiasis a network meta analysis |
| topic | vulvovaginal candidiasis commercial Chinese polyherbal preparation (CCPP) Chinese patent medicine traditional Chinese medicine (TCM) anti-fungal drugs network meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1484325/full |
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